Synonym
G5-7; G57; G-5-7; G5 7; G-5 7; JAK2 inhibitor G5-7
IUPAC/Chemical Name
tert-butyl 3,5-bis((Z)-2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate
InChi Key
MCSPIRBNMDODQP-BKHHGCLFSA-N
InChi Code
InChI=1S/C24H23F2NO3/c1-24(2,3)30-23(29)27-14-18(12-16-8-4-6-10-20(16)25)22(28)19(15-27)13-17-9-5-7-11-21(17)26/h4-13H,14-15H2,1-3H3/b18-12-,19-13-
SMILES Code
O=C(N1C/C(C(/C(C1)=C\C2=CC=CC=C2F)=O)=C/C3=CC=CC=C3F)OC(C)(C)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
411.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Paniagua R, García-López E, Ávila-Díaz M, Ventura MD, Orihuela O, Prado-Uribe
MD, Gallardo-Montoya JM, Lindholm B. Sex Modulates Cardiovascular Effects of
Icodextrin-Based Peritoneal Dialysis Solutions. Front Physiol. 2022 May
23;13:911072. doi: 10.3389/fphys.2022.911072. PMID: 35677090; PMCID: PMC9168216.
2: He K, Qi Q, Chan CB, Xiao G, Liu X, Tucker-Burden C, Wang L, Mao H, Lu X,
McDonald FE, Luo H, Fan QW, Weiss WA, Sun SY, Brat DJ, Ye K. Blockade of glioma
proliferation through allosteric inhibition of JAK2. Sci Signal. 2013 Jul
9;6(283):ra55. doi: 10.1126/scisignal.2003900. PMID: 23838182; PMCID:
PMC4772155.
