Hinokiflavone, a naturally occurring biflavonoid isolated from various plant species such as Selaginella and Cupressaceae members, exhibits a range of bioactivities. It has demonstrated anticancer properties, notably by inducing apoptosis and cell cycle arrest in several cancer cell lines including A549 (lung), HepG2 (liver), and MCF-7 (breast), with IC₅₀ values ranging from 3.8 to 20 μM depending on the cell line. Hinokiflavone also shows anti-inflammatory activity by inhibiting NF-κB signaling and reducing pro-inflammatory cytokines like IL-6 and TNF-α. Furthermore, it has antiviral effects, including activity against herpes simplex virus (HSV-1) and dengue virus. Mechanistically, hinokiflavone is known to inhibit splicing factor 3B subunit 1 (SF3B1), implicating it in pre-mRNA splicing regulation, which may underlie its antiproliferative effects. Its broad pharmacological profile supports its potential as a lead compound for further drug development.
MedKoo Cat#: 123044
Name: Hinokiflavone
CAS#: 19202-36-9
Chemical Formula: C30H18O10
Exact Mass: 538.0900
Molecular Weight: 538.46
Elemental Analysis: C, 66.92; H, 3.37; O, 29.71
The following data is based on the product molecular weight 538.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
