LL-K8-22 is a selective, durable, and small-molecule degrader of the CDK8-cyclin C complex. LL-K8-22 significantly degraded CDK8 without reducing CDK19 and did not degrade other cyclin proteins except cyclin C. Moreover, LL-K8-22 showed enhanced anti-proliferative effects over its parental molecule, BI-1347, with potency increased by 5-fold in MDA-MB-468 cells. LL-K8-22 inhibited E2F- and MYC-driven carcinogenic transcriptional programs.
MedKoo Cat#: 123015
Name: LL-K8-22
CAS#: N/A
Chemical Formula: C37H43N5O
Exact Mass: 573.3500
Molecular Weight: 573.79
Elemental Analysis: C, 77.45; H, 7.55; N, 12.21; O, 2.79
The following data is based on the product molecular weight 573.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
