MedKoo Cat#: 123002 | Name: YAN50563
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

YAN50563, also known as Me VH 032, amine, is a derivative of the von Hippel-Lindau (VHL) ligand, VH 032 for use as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.

Chemical Structure

YAN50563
YAN50563
CAS#2504950-56-3

Theoretical Analysis

MedKoo Cat#: 123002

Name: YAN50563

CAS#: 2504950-56-3

Chemical Formula: C23H34Cl2N4O3S

Exact Mass: 516.1700

Molecular Weight: 517.51

Elemental Analysis: C, 53.38; H, 6.62; Cl, 13.70; N, 10.83; O, 9.27; S, 6.20

Price and Availability

Size Price Availability Quantity
100mg USD 800.00 2 Weeks
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Related CAS #
No Data
Synonym
Me VH 032, amine; E3 ligase Ligand 1 dihydrochloride; VHL ligand 2 dihydrochloride; AMY27708
IUPAC/Chemical Name
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide dihydrochloride
InChi Key
YTJDUDNKHHNDRD-ARZBPYMHSA-N
InChi Code
InChI=1S/C23H32N4O3S.2ClH/c1-13(15-6-8-16(9-7-15)19-14(2)25-12-31-19)26-21(29)18-10-17(28)11-27(18)22(30)20(24)23(3,4)5;;/h6-9,12-13,17-18,20,28H,10-11,24H2,1-5H3,(H,26,29);2*1H/t13-,17+,18-,20+;;/m0../s1
SMILES Code
CC1=C(C2=CC=C(C=C2)[C@H](C)NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)N)=O)O)=O)SC=N1.Cl.Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 517.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL