MedKoo Cat#: 122993 | Name: VH 101, thiol
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VH 101, thiol is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development

Chemical Structure

VH 101, thiol
VH 101, thiol
CAS#2358775-81-0

Theoretical Analysis

MedKoo Cat#: 122993

Name: VH 101, thiol

CAS#: 2358775-81-0

Chemical Formula: C25H31FN4O4S2

Exact Mass: 534.1800

Molecular Weight: 534.67

Elemental Analysis: C, 56.16; H, 5.84; F, 3.55; N, 10.48; O, 11.97; S, 11.99

Price and Availability

Size Price Availability Quantity
50mg USD 1,050.00 2 Weeks
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Related CAS #
No Data
Synonym
VH 101-thiol; VH 101 thiol ; VH-101 thiol
IUPAC/Chemical Name
(2S,4R)-1-((R)-2-(1-fluorocyclopropane-1-carboxamido)-3-mercapto-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChi Key
RCVHBJGYHDKFGZ-WSTZPKSXSA-N
InChi Code
InChI=1S/C25H31FN4O4S2/c1-14-19(36-13-28-14)16-6-4-15(5-7-16)11-27-21(32)18-10-17(31)12-30(18)22(33)20(24(2,3)35)29-23(34)25(26)8-9-25/h4-7,13,17-18,20,31,35H,8-12H2,1-3H3,(H,27,32)(H,29,34)/t17-,18+,20-/m1/s1
SMILES Code
O=C(C1(CC1)F)N[C@@H](C(C)(S)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C4=C(N=CS4)C)C=C3)=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 534.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Liu X, Kalogeropulou AF, Domingos S, Makukhin N, Nirujogi RS, Singh F, Shpiro N, Saalfrank A, Sammler E, Ganley IG, Moreira R, Alessi DR, Ciulli A. Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2. J Am Chem Soc. 2022 Sep 21;144(37):16930-16952. doi: 10.1021/jacs.2c05499. Epub 2022 Aug 25. PMID: 36007011; PMCID: PMC9501899.