MedKoo Cat#: 130314 | Name: NBI-12i

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NBI-12i is a melanocortin-4 receptor (MC4-R) antagonist that is able to enter the nervous system and was found to reduce uremia-associated cachexia in mice.

Chemical Structure

NBI-12i
NBI-12i
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130314

Name: NBI-12i

CAS#: N/A

Chemical Formula: C25H36Cl2N4O4

Exact Mass: 526.2114

Molecular Weight: 527.49

Elemental Analysis: C, 56.93; H, 6.88; Cl, 13.44; N, 10.62; O, 12.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NBI-12i; NBI12i; NBI 12i
IUPAC/Chemical Name
ethyl (1S,2S)-2-(4-((R)-2-(3-aminopropanamido)-3-(2,4-dichlorophenyl)propanoyl)piperazin-1-yl)cyclohexane-1-carboxylate
InChi Key
BHZMEZUGBXLPOY-NNWRFLSQSA-N
InChi Code
InChI=1S/C25H36Cl2N4O4/c1-2-35-25(34)19-5-3-4-6-22(19)30-11-13-31(14-12-30)24(33)21(29-23(32)9-10-28)15-17-7-8-18(26)16-20(17)27/h7-8,16,19,21-22H,2-6,9-15,28H2,1H3,(H,29,32)/t19-,21+,22-/m0/s1
SMILES Code
O=C([C@@H]1[C@@H](N2CCN(C([C@H](NC(CCN)=O)CC3=CC=C(Cl)C=C3Cl)=O)CC2)CCCC1)OCC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 527.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Cheung WW, Kuo HJ, Markison S, Chen C, Foster AC, Marks DL, Mak RH. Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice. J Am Soc Nephrol. 2007 Sep;18(9):2517-24. doi: 10.1681/ASN.2006091024. Epub 2007 Aug 8. PMID: 17687077. 2. Markison S, Foster AC, Chen C, Brookhart GB, Hesse A, Hoare SR, Fleck BA, Brown BT, Marks DL. The regulation of feeding and metabolic rate and the prevention of murine cancer cachexia with a small-molecule melanocortin-4 receptor antagonist. Endocrinology. 2005 Jun;146(6):2766-73. doi: 10.1210/en.2005-0142. Epub 2005 Mar 17. PMID: 15774557.