Landornamide A | CAS#N/A | antiviral

MedKoo Cat#: 130302 | Name: Landornamide A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Landornamide A is a RiPP with antiviral properties.

Chemical Structure

Landornamide A

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130302

Name: Landornamide A

CAS#: N/A

Chemical Formula: C69H103N19O18S2

Exact Mass: 1549.7170

Molecular Weight: 1550.82

Elemental Analysis: C, 53.44; H, 6.69; N, 17.16; O, 18.57; S, 4.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Landornamide A

IUPAC/Chemical Name

((2S)-2-((6R,9S,15R)-15-(2-((2S)-2-((9S,12R,15S,18R)-15-((1H-indol-3-yl)methyl)-18-(2-aminoacetamido)-12-((S)-sec-butyl)-9-methyl-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacyclononadecane-3-carboxamido)-5-aminopentanamido)acetamido)-9-benzyl-6-isopropyl-2-methyl-5,8,11,14-tetraoxo-1-thia-4,7,10,13-tetraazacyclohexadecane-3-carboxamido)-5-aminopentanoyl)-L-threonine

InChi Key

ULTOBTMZTQDCLE-DYFGBKDTSA-N

InChi Code

InChI=1S/C69H103N19O18S2/c1-8-35(4)55-67(103)77-36(5)58(94)74-28-52(92)80-48(32-107-31-47(79-50(90)26-72)65(101)84-46(63(99)86-55)25-40-27-73-42-19-13-12-18-41(40)42)64(100)82-43(20-14-22-70)59(95)75-30-53(93)81-49-33-108-38(7)57(68(104)83-44(21-15-23-71)61(97)87-56(37(6)89)69(105)106)88-66(102)54(34(2)3)85-62(98)45(24-39-16-10-9-11-17-39)78-51(91)29-76-60(49)96/h9-13,16-19,27,34-38,43-49,54-57,73,89H,8,14-15,20-26,28-33,70-72H2,1-7H3,(H,74,94)(H,75,95)(H,76,96)(H,77,103)(H,78,91)(H,79,90)(H,80,92)(H,81,93)(H,82,100)(H,83,104)(H,84,101)(H,85,98)(H,86,99)(H,87,97)(H,88,102)(H,105,106)/t35-,36-,37+,38?,43-,44-,45-,46-,47-,48?,49-,54+,55+,56-,57?/m0/s1

SMILES Code

C[C@@H](O)[C@H](NC([C@@H](NC(C(NC([C@@H](C(C)C)NC([C@H](CC1=CC=CC=C1)NC(CN2)=O)=O)=O)C(C)SC[C@H](NC(CNC([C@@H](NC(C(NC(CNC([C@H](C)NC([C@@H]([C@H](CC)C)NC([C@H](CC3=CNC4=C3C=CC=C4)N5)=O)=O)=O)=O)CSC[C@H](NC(CN)=O)C5=O)=O)CCCN)=O)=O)C2=O)=O)CCCN)=O)C(O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,550.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Mordhorst S, Badmann T, Bösch NM, Morinaka BI, Rauch H, Piel J, Groll M, Vagstad AL. Structural and Biochemical Insights into Post-Translational Arginine-to-Ornithine Peptide Modifications by an Atypical Arginase. ACS Chem Biol. 2023 Feb 15. doi: 10.1021/acschembio.2c00879. Epub ahead of print. PMID: 36791048. 2. Mordhorst S, Morinaka BI, Vagstad AL, Piel J. Posttranslationally Acting Arginases Provide a Ribosomal Route to Non-proteinogenic Ornithine Residues in Diverse Peptide Sequences. Angew Chem Int Ed Engl. 2020 Nov 23;59(48):21442-21447. doi: 10.1002/anie.202008990. Epub 2020 Sep 17. PMID: 32780902. 3. Bösch NM, Borsa M, Greczmiel U, Morinaka BI, Gugger M, Oxenius A, Vagstad AL, Piel J. Landornamides: Antiviral Ornithine-Containing Ribosomal Peptides Discovered through Genome Mining. Angew Chem Int Ed Engl. 2020 Jul 13;59(29):11763-11768. doi: 10.1002/anie.201916321. Epub 2020 May 18. PMID: 32163654.