MedKoo Cat#: 130301 | Name: MM0299
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MM0299 is a lanosterol synthase (LSS) inhibitor for the treatment of glioblastoma. MM0299 leads to the synthesis of 24(S),25-epoxycholesterol, preventing growth of tumor cells through the depletion of cellular cholesterol.

Chemical Structure

MM0299
CAS#474255-10-2

Theoretical Analysis

MedKoo Cat#: 130301

Name: MM0299

CAS#: 474255-10-2

Chemical Formula: C26H23NO5

Exact Mass: 429.1576

Molecular Weight: 429.47

Elemental Analysis: C, 72.71; H, 5.40; N, 3.26; O, 18.63

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
MM0299; MM-0299; MM 0299
IUPAC/Chemical Name
2-(4-(2-(4-methoxyphenyl)-2-oxoethoxy)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
InChi Key
SYUJAWVNBGZCNK-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H23NO5/c1-31-16-6-2-14(3-7-16)22(28)13-32-17-8-4-15(5-9-17)27-25(29)23-18-10-11-19(21-12-20(18)21)24(23)26(27)30/h2-11,18-21,23-24H,12-13H2,1H3
SMILES Code
O=C1N(C2=CC=C(OCC(C3=CC=C(OC)C=C3)=O)C=C2)C(C4C5C(C6)C6C(C=C5)C14)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 429.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Nguyen TP, Wang W, Sternisha AC, Corley CD, Wang HL, Wang X, Ortiz F, Lim SK, Abdullah KG, Parada LF, Williams NS, McBrayer SK, McDonald JG, De Brabander JK, Nijhawan D. Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production. Cell Chem Biol. 2023 Feb 16;30(2):214-229.e18. doi: 10.1016/j.chembiol.2023.01.005. Epub 2023 Feb 8. PMID: 36758549; PMCID: PMC10008516.