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MedKoo Cat#: 122950 | Name: HR011303

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HR011303 is human uric acid transporter inhibitor.

Chemical Structure

HR011303
HR011303
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 122950

Name: HR011303

CAS#: N/A

Chemical Formula: C14H12BrNO2S

Exact Mass: 336.9800

Molecular Weight: 338.22

Elemental Analysis: C, 49.72; H, 3.58; Br, 23.62; N, 4.14; O, 9.46; S, 9.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
HR011303; HR-011303; HR 011303
IUPAC/Chemical Name
1-((6-bromoquinolin-4-yl)thio)cyclobutane-1-carboxylic acid
InChi Key
QGBWIYLNOBYNDL-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H12BrNO2S/c15-9-2-3-11-10(8-9)12(4-7-16-11)19-14(13(17)18)5-1-6-14/h2-4,7-8H,1,5-6H2,(H,17,18)
SMILES Code
BrC1=CC2=C(N=CC=C2SC3(C(O)=O)CCC3)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 338.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Guo Z, Liu M, Meng J, Xue Y, Huang Q, Zheng Y, Wu Y, Chen Z, Yu J, Zhong D, Li G, Chen X, Diao X. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats. Drug Metab Dispos. 2022 Jun;50(6):809-818. doi: 10.1124/dmd.121.000582. Epub 2021 Dec 3. PMID: 34862251. 2: Zheng Y, Zhang H, Liu M, Li G, Ma S, Zhang Z, Lin H, Zhan Y, Chen Z, Zhong D, Miao L, Diao X. Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase. Drug Metab Dispos. 2022 Jun;50(6):798-808. doi: 10.1124/dmd.121.000581. Epub 2021 Dec 3. PMID: 34862252. 3: Wang J, Yao W, Fan D, Qiu Z, Song J, Pan K, Hang T. An LC-MS/MS method for quantification of HR011303, a novel highly selective urate transporter 1 inhibitor in beagle dogs and the application to a pharmacokinetic study. Biomed Chromatogr. 2019 Oct;33(10):e4604. doi: 10.1002/bmc.4604. Epub 2019 Jun 24. PMID: 31128076.