SHM115 is an efficacious Mitochondrial Uncoupler in the Prevention of Diet-Induced Obesity. SHM115, which contains a pentafluoro aniline, had an EC50 value of 17 μM and exhibited 75% oral bioavailability. SHM115 treatment increased the energy expenditure and lowered the body fat mass in two diet-induced obesity mouse models, including an obesity prevention model and an obesity reversal model.
MedKoo Cat#: 122945
Name: SHM115
CAS#: N/A
Chemical Formula: C11H3F5N4O2
Exact Mass: 318.0200
Molecular Weight: 318.16
Elemental Analysis: C, 41.53; H, 0.95; F, 29.86; N, 17.61; O, 10.06
The following data is based on the product molecular weight 318.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
