MedKoo Cat#: 130298 | Name: SYHA1815

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SYHA1815 is a RET inhibitor for the treatment of certain cancers. SYHA1815 downregulates c-Myc, which, in turn, leads to G1 cell-cycle arrest, resulting in antiproliferative effects.

Chemical Structure

SYHA1815
SYHA1815
CAS#2760195-67-1

Theoretical Analysis

MedKoo Cat#: 130298

Name: SYHA1815

CAS#: 2760195-67-1

Chemical Formula: C27H26ClF4N5O

Exact Mass: 547.1762

Molecular Weight: 547.98

Elemental Analysis: C, 59.18; H, 4.78; Cl, 6.47; F, 13.87; N, 12.78; O, 2.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SYHA1815; SYHA 1815; SYHA-1815
IUPAC/Chemical Name
3-((2-aminopyridin-3-yl)ethynyl)-5-fluoro-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride
InChi Key
SWMFIGMUMWFQHQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H25F4N5O.ClH/c1-35-9-11-36(12-10-35)17-20-6-7-23(16-24(20)27(29,30)31)34-26(37)21-13-18(14-22(28)15-21)4-5-19-3-2-8-33-25(19)32;/h2-3,6-8,13-16H,9-12,17H2,1H3,(H2,32,33)(H,34,37);1H
SMILES Code
O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)C3=CC(F)=CC(C#CC4=CC=CN=C4N)=C3.[H]Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 547.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Jiang Y, Peng X, Ji Y, Dai Y, Fang Y, Xiong B, Ren W, Hu Y, Chen Y, Ai J. The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation. Mol Cancer Ther. 2021 Nov;20(11):2198-2206. doi: 10.1158/1535-7163.MCT-21-0127. Epub 2021 Sep 13. PMID: 34518294.