Synonym
CB10277; CB10-277; CB10 277; 1pcarboxy33dimethylphenyltriazine.
IUPAC/Chemical Name
(E)-4-(3,3-dimethyltriaz-1-en-1-yl)benzoic acid
InChi Key
GUAZPUYTLMUTMA-ZHACJKMWSA-N
InChi Code
InChI=1S/C9H11N3O2/c1-12(2)11-10-8-5-3-7(4-6-8)9(13)14/h3-6H,1-2H3,(H,13,14)/b11-10+
SMILES Code
O=C(O)C1=CC=C(/N=N/N(C)C)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>5 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
193.20
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bleehen NM, Calvert AH, Lee SM, Harper P, Kaye SB, Judson I, Brampton M. A Cancer Research Campaign (CRC) phase II trial of CB10-277 given by 24 hour infusion for malignant melanoma. Br J Cancer. 1994 Oct;70(4):775-7. PubMed PMID: 7917939; PubMed Central PMCID: PMC2033397.
2: Lee SM, O'Connor PJ, Thatcher N, Crowther D, Margison GP, Cooper DP. Relationships between the formation of O6-methyldeoxyguanosine by 1-p-carboxyl-3,3-dimethylphenyltriazene in DNA and O6-alkylguanine-DNA alkyltransferase in human peripheral leukocytes. Cancer Res. 1994 Aug 1;54(15):4072-6. PubMed PMID: 8033139.
3: Foster BJ, Newell DR, Gumbrell LA, Jenns KE, Calvert AH. Phase I trial with pharmacokinetics of CB10-277 given by 24 hours continuous infusion. Br J Cancer. 1993 Feb;67(2):369-73. PubMed PMID: 8431368; PubMed Central PMCID: PMC1968159.
4: Foster BJ, Newell DR, Carmichael J, Harris AL, Gumbrell LA, Jones M, Goodard PM, Calvert AH. Preclinical, phase I and pharmacokinetic studies with the dimethyl phenyltriazene CB10-277. Br J Cancer. 1993 Feb;67(2):362-8. PubMed PMID: 8431367; PubMed Central PMCID: PMC1968184.
5: Lee SM, Thatcher N, Crowther D, Margison GP. In vivo depletion of O6-alkylguanine-DNA-alkyltransferase in lymphocytes and melanoma of patients treated with CB 10-277, a new DTIC analogue. Cancer Chemother Pharmacol. 1992;31(3):240-6. PubMed PMID: 1464162.
