JR1-157 is a σ2R ligand that binds σ2R with a Ki of 47 nM. JR1-157 shows promise as a potential treatment for pancreatic cancer, as σ2R is often overexpressed in cancers, making it the ideal target for preventing/reducing tumor proliferation. JR1-157 was also found to increase the expression of LC3B.
MedKoo Cat#: 130277
Name: JR1-157
CAS#: N/A
Chemical Formula: C23H29ClN6O
Exact Mass: 440.2091
Molecular Weight: 440.98
Elemental Analysis: C, 62.65; H, 6.63; Cl, 8.04; N, 19.06; O, 3.63
The following data is based on the product molecular weight 440.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |