MedKoo Cat#: 130277 | Name: JR1-157

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JR1-157 is a σ2R ligand that binds σ2R with a Ki of 47 nM. JR1-157 shows promise as a potential treatment for pancreatic cancer, as σ2R is often overexpressed in cancers, making it the ideal target for preventing/reducing tumor proliferation. JR1-157 was also found to increase the expression of LC3B.

Chemical Structure

JR1-157
JR1-157
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130277

Name: JR1-157

CAS#: N/A

Chemical Formula: C23H29ClN6O

Exact Mass: 440.2091

Molecular Weight: 440.98

Elemental Analysis: C, 62.65; H, 6.63; Cl, 8.04; N, 19.06; O, 3.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JR1-157; JR1 157; NSC-807353; NSC807353; NSC 807353
IUPAC/Chemical Name
N-(5-chloroquinolin-8-yl)-5-((5-(diethylamino)pentan-2-yl)amino)pyrazine-2-carboxamide
InChi Key
KRUQRZWHJYOOJH-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H29ClN6O/c1-4-30(5-2)13-7-8-16(3)28-21-15-26-20(14-27-21)23(31)29-19-11-10-18(24)17-9-6-12-25-22(17)19/h6,9-12,14-16H,4-5,7-8,13H2,1-3H3,(H,27,28)(H,29,31)
SMILES Code
O=C(C1=NC=C(NC(CCCN(CC)CC)C)N=C1)NC2=C3N=CC=CC3=C(Cl)C=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 440.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Roy J, Kyani A, Hanafi M, Xu Y, Takyi-Williams J, Sun D, Osman EEA, Neamati N. Design and Synthesis of Orally Active Quinolyl Pyrazinamides as Sigma 2 Receptor Ligands for the Treatment of Pancreatic Cancer. J Med Chem. 2023 Feb 9;66(3):1990-2019. doi: 10.1021/acs.jmedchem.2c01769. Epub 2023 Jan 24. PMID: 36692906.