Synonym
VAF347; VAF 347; VAF-347
IUPAC/Chemical Name
4-(3-chlorophenyl)-N-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine
InChi Key
XTKUZTBZRIJTFR-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H11ClF3N3/c18-13-3-1-2-11(10-13)15-8-9-22-16(24-15)23-14-6-4-12(5-7-14)17(19,20)21/h1-10H,(H,22,23,24)
SMILES Code
FC(C1=CC=C(C=C1)NC2=NC=CC(C3=CC(Cl)=CC=C3)=N2)(F)F
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
349.74
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zapadka TE, Lindstrom SI, Batoki JC, Lee CA, Taylor BE, Howell SJ, Taylor PR.
Aryl Hydrocarbon Receptor Agonist VAF347 Impedes Retinal Pathogenesis in
Diabetic Mice. Int J Mol Sci. 2021 Apr 21;22(9):4335. doi: 10.3390/ijms22094335.
PMID: 33919327; PMCID: PMC8122442.
2: Ibabao CN, Bunaciu RP, Schaefer DM, Yen A. The AhR agonist VAF347 augments
retinoic acid-induced differentiation in leukemia cells. FEBS Open Bio. 2015 Apr
8;5:308-18. doi: 10.1016/j.fob.2015.04.002. PMID: 25941627; PMCID: PMC4412882.
3: Baba N, Rubio M, Kenins L, Regairaz C, Woisetschlager M, Carballido JM,
Sarfati M. The aryl hydrocarbon receptor (AhR) ligand VAF347 selectively acts on
monocytes and naïve CD4(+) Th cells to promote the development of
IL-22-secreting Th cells. Hum Immunol. 2012 Aug;73(8):795-800. doi:
10.1016/j.humimm.2012.05.002. Epub 2012 May 17. PMID: 22609446.
4: Lawrence BP, Denison MS, Novak H, Vorderstrasse BA, Harrer N, Neruda W,
Reichel C, Woisetschläger M. Activation of the aryl hydrocarbon receptor is
essential for mediating the anti-inflammatory effects of a novel low-molecular-
weight compound. Blood. 2008 Aug 15;112(4):1158-65. doi:
10.1182/blood-2007-08-109645. Epub 2008 Feb 12. PMID: 18270326; PMCID:
PMC2515129.
5: Platzer B, Richter S, Kneidinger D, Waltenberger D, Woisetschläger M, Strobl
H. Aryl hydrocarbon receptor activation inhibits in vitro differentiation of
human monocytes and Langerhans dendritic cells. J Immunol. 2009 Jul
1;183(1):66-74. doi: 10.4049/jimmunol.0802997. Epub 2009 Jun 17. PMID: 19535631.
