Synonym
Bequinostatin C; DTXSID70164966
IUPAC/Chemical Name
1,7,9,11-tetrahydroxy-8,13-dioxo-3-pentyl-8,13-dihydrobenzo[a]tetracene-2-carboxylic acid
InChi Key
NJGDHHRUAFIFFQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H22O8/c1-2-3-4-5-12-8-13-6-7-15-16(20(13)26(33)21(12)28(35)36)11-18-23(25(15)32)27(34)22-17(24(18)31)9-14(29)10-19(22)30/h6-11,29-30,32-33H,2-5H2,1H3,(H,35,36)
SMILES Code
O=C(O)C1=C(O)C2=C(C=C34)C(C(O)=C3C(C5=C(O)C=C(O)C=C5C4=O)=O)=CC=C2C=C1CCCCC
Purity
>90% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
486.48
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lackner G, Schenk A, Xu Z, Reinhardt K, Yunt ZS, Piel J, Hertweck C. Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways. J Am Chem Soc. 2007 Aug 1;129(30):9306-12. doi: 10.1021/ja0718624. Epub 2007 Jul 11. PMID: 17625850.
2: Aoyama T, Kojima F, Abe F, Muraoka Y, Naganawa H, Takeuchi T, Aoyagi T. Bequinostatins A and B new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities. J Antibiot (Tokyo). 1993 Jun;46(6):914-20. doi: 10.7164/antibiotics.46.914. PMID: 8344872.
3: Yamazaki T, Tatee T, Aoyama, Kojima F, Takeuchi T, Aoyagi T. Bequinostatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. J Antibiot (Tokyo). 1993 Aug;46(8):1309-11. doi: 10.7164/antibiotics.46.1309. PMID: 8407595.
