G12Si-1 | CAS#N/A | K-Ras(G12S) inhibitor

MedKoo Cat#: 130236 | Name: G12Si-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

G12Si-1 is a K-Ras(G12S) inhibitor that covalently binds to the somatic mutation, G12S, in K-Ras, suppressing oncogenic activity.

Chemical Structure

G12Si-1

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130236

Name: G12Si-1

CAS#: N/A

Chemical Formula: C29H32ClN5O3

Exact Mass: 533.2194

Molecular Weight: 534.06

Elemental Analysis: C, 65.22; H, 6.04; Cl, 6.64; N, 13.11; O, 8.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

G12Si-1; G12Si1; G12Si 1

IUPAC/Chemical Name

(1R,6R)-3-(7-(8-chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-8-oxa-3-azabicyclo[4.2.0]octan-7-one

InChi Key

VKLRGERKXJSQFY-HWHXTQLESA-N

InChi Code

InChI=1S/C29H32ClN5O3/c1-33-12-4-7-19(33)17-37-29-31-23-15-34(24-9-3-6-18-5-2-8-22(30)26(18)24)13-10-20(23)27(32-29)35-14-11-21-25(16-35)38-28(21)36/h2-3,5-6,8-9,19,21,25H,4,7,10-17H2,1H3/t19-,21+,25-/m0/s1

SMILES Code

O=C1[C@]2([H])CCN(C3=C4C(CN(C5=C6C(Cl)=CC=CC6=CC=C5)CC4)=NC(OC[C@H]7N(C)CCC7)=N3)C[C@]2([H])O1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 534.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Zhang Z, Guiley KZ, Shokat KM. Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S). Nat Chem Biol. 2022 Nov;18(11):1177-1183. doi: 10.1038/s41589-022-01065-9. Epub 2022 Jul 21. PMID: 35864332; PMCID: PMC9596369.