ET516 | CAS#N/A | AR inhibitor| MedKoo

MedKoo Cat#: 130232 | Name: ET516

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ET516 is an androgen receptor inhibitor that disrupts AR condensates, leading to the suppression of transcriptional activity of the AR and results in antitumor activity in prostate cancer cells containingAR-resistant mutants.

Chemical Structure

ET516

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130232

Name: ET516

CAS#: N/A

Chemical Formula: C25H22Cl2N4O3S

Exact Mass: 528.0790

Molecular Weight: 529.44

Elemental Analysis: C, 56.72; H, 4.19; Cl, 13.39; N, 10.58; O, 9.07; S, 6.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ET516; ET 516; ET-516

IUPAC/Chemical Name

N-(5-((4-(2-(3-chloro-4-(2-chloroethoxy)-5-cyanophenyl)propan-2-yl)phenyl)ethynyl)pyrimidin-2-yl)methanesulfonamide

InChi Key

KNUXMQQPYYHTJD-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H22Cl2N4O3S/c1-25(2,21-12-19(14-28)23(22(27)13-21)34-11-10-26)20-8-6-17(7-9-20)4-5-18-15-29-24(30-16-18)31-35(3,32)33/h6-9,12-13,15-16H,10-11H2,1-3H3,(H,29,30,31)

SMILES Code

CS(=O)(NC1=NC=C(C#CC2=CC=C(C(C)(C3=CC(C#N)=C(OCCCl)C(Cl)=C3)C)C=C2)C=N1)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 529.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Xie J, He H, Kong W, Li Z, Gao Z, Xie D, Sun L, Fan X, Jiang X, Zheng Q, Li G, Zhu J, Zhu G. Targeting androgen receptor phase separation to overcome antiandrogen resistance. Nat Chem Biol. 2022 Dec;18(12):1341-1350. doi: 10.1038/s41589-022-01151-y. Epub 2022 Oct 13. PMID: 36229685.