TM-25659 | CAS#260553-97-7 | TAZ agonist

MedKoo Cat#: 130223 | Name: TM-25659

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TM-25659 is a TAZ agonist that plays an important role in cell proliferation and differentiation. TM-25659 has been shown to enhance osteogenic differentiation and interact with peroxisome proliferator-activated receptor gamma, inhibiting differentiation of adipocytes for the reduction of insulin resistance.

Chemical Structure

TM-25659

CAS#260553-97-7

Theoretical Analysis

MedKoo Cat#: 130223

Name: TM-25659

CAS#: 260553-97-7

Chemical Formula: C30H28N8

Exact Mass: 500.2437

Molecular Weight: 500.61

Elemental Analysis: C, 71.98; H, 5.64; N, 22.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

TM-25659; TM25659; TM 25659

IUPAC/Chemical Name

3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-5-methyl-6-(pyridin-3-yl)-3H-imidazo[4,5-b]pyridine

InChi Key

KCOQNLYGMQJUJD-UHFFFAOYSA-N

InChi Code

InChI=1S/C30H28N8/c1-3-4-11-28-33-27-17-26(23-8-7-16-31-18-23)20(2)32-30(27)38(28)19-21-12-14-22(15-13-21)24-9-5-6-10-25(24)29-34-36-37-35-29/h5-10,12-18H,3-4,11,19H2,1-2H3,(H,34,35,36,37)

SMILES Code

CC1=C(C2=CC=CN=C2)C=C3C(N(CC4=CC=C(C5=CC=CC=C5C6=NNN=N6)C=C4)C(CCCC)=N3)=N1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 500.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Huang H, Lu Q, Ye C, Wei M, Yang C, Zhang L, Huang Y, Luo X, Luo J. TAZ promotes osteogenic differentiation of mesenchymal stem cells line C3H10T1/2, murine multi-lineage cells lines C2C12, and MEFs induced by BMP9. Cell Death Discov. 2022 Dec 27;8(1):499. doi: 10.1038/s41420-022-01292-y. PMID: 36575168; PMCID: PMC9794779. 2. Kodaka M, Mao F, Arimoto-Matsuzaki K, Kitamura M, Xu X, Yang Z, Nakagawa K, Maruyama J, Ishii K, Akazawa C, Oyaizu T, Yamamoto N, Ishigami-Yuasa M, Tsuemoto N, Ito S, Kagechika H, Nishina H, Hata Y. Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells. PLoS One. 2020 Apr 8;15(4):e0231265. doi: 10.1371/journal.pone.0231265. PMID: 32267872; PMCID: PMC7141682. 3. Zhu Y, Wu Y, Cheng J, Wang Q, Li Z, Wang Y, Wang D, Wang H, Zhang W, Ye J, Jiang H, Wang L. Pharmacological activation of TAZ enhances osteogenic differentiation and bone formation of adipose-derived stem cells. Stem Cell Res Ther. 2018 Mar 7;9(1):53. doi: 10.1186/s13287-018-0799-z. PMID: 29514703; PMCID: PMC5842656. 4. Jung JG, Yi SA, Choi SE, Kang Y, Kim TH, Jeon JY, Bae MA, Ahn JH, Jeong H, Hwang ES, Lee KW. TM-25659-Induced Activation of FGF21 Level Decreases Insulin Resistance and Inflammation in Skeletal Muscle via GCN2 Pathways. Mol Cells. 2015 Dec;38(12):1037-43. doi: 10.14348/molcells.2015.0100. Epub 2015 Nov 4. PMID: 26537193; PMCID: PMC4696994. 5. Men T, Piao SH, Teng CB. [Regulation of differentiation of mesenchymal stem cells by the Hippo pathway effectors TAZ/YAP]. Yi Chuan. 2013 Nov;35(11):1283-90. Chinese. doi: 10.3724/sp.j.1005.2013.01283. PMID: 24579311. 6. Choi MK, Kwon M, Ahn JH, Kim NJ, Bae MA, Song IS. Transport characteristics and transporter-based drug-drug interactions of TM-25659, a novel TAZ modulator. Biopharm Drug Dispos. 2014 Apr;35(3):183-94. doi: 10.1002/bdd.1883. Epub 2013 Dec 18. PMID: 24285344. 7. Lee KR, Choi SH, Song JS, Kwak EY, Chae YJ, Im SH, Lee BH, Seo H, Cho WK, Kim MS, Kim NJ, Ahn SH, Bae MA. Pharmacokinetic characterization of the novel TAZ modulator TM-25659 using a multicompartment kinetic model in rats and a possibility of its drug-drug interactions in humans. Xenobiotica. 2013 Feb;43(2):193-200. doi: 10.3109/00498254.2012.709953. Epub 2012 Aug 3. PMID: 22856387. 8. Choi SH, Lee KR, Woo JC, Kim NJ, Moon DC, Hwang ES, Ahn SH, Bae MA, Kim MS. Determination of a novel TAZ modulator, 2-butyl-5-methyl-6-(pyridine-3-yl)-3-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-3H imidazo[4,5-b]pyridine] (TM-25659) in rat plasma by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2012 Apr 7;63:47-52. doi: 10.1016/j.jpba.2012.01.036. Epub 2012 Feb 7. PMID: 22357285. 9. Jang EJ, Jeong H, Kang JO, Kim NJ, Kim MS, Choi SH, Yoo SE, Hong JH, Bae MA, Hwang ES. TM-25659 enhances osteogenic differentiation and suppresses adipogenic differentiation by modulating the transcriptional co-activator TAZ. Br J Pharmacol. 2012 Mar;165(5):1584-94. doi: 10.1111/j.1476-5381.2011.01664.x. PMID: 21913895; PMCID: PMC3372739.