Synonym
SHC014748M; SHC 014748M
IUPAC/Chemical Name
(S)-4-amino-6-((1-(8-chloro-4-oxo-2-phenyl-1,4-dihydroquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile methanesulfonate
InChi Key
GUZPLFWFFSZBIA-YDALLXLXSA-N
InChi Code
InChI=1S/C22H17ClN6O.CH4O3S/c1-12(28-22-15(10-24)21(25)26-11-27-22)17-18(13-6-3-2-4-7-13)29-19-14(20(17)30)8-5-9-16(19)23;1-5(2,3)4/h2-9,11-12H,1H3,(H,29,30)(H3,25,26,27,28);1H3,(H,2,3,4)/t12-;/m0./s1
SMILES Code
N#CC1=C(N[C@H](C2=C(C3=CC=CC=C3)NC4=C(C=CC=C4Cl)C2=O)C)N=CN=C1N.OS(=O)(C)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
512.97
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. https://clinicaltrials.gov/ct2/show/results/NCT04431089
2. Fan L, Wang C, Zhao L, Wang Z, Zhang X, Liu X, Cao L, Xu W, Li J. SHC014748M, a novel selective inhi-bitor of PI3Kδ, demonstrates promising preclinical antitumor activity in B cell lymphomas and chronic lymphocytic leukemia. Neoplasia. 2020 Dec;22(12):714-724. doi: 10.1016/j.neo.2020.10.004. Epub 2020 Oct 23. PMID: 33142237; PMCID: PMC7586065.
3. Guo F, Liu B, Li X, Wang H, Zhu X, Su Y, He C, Zhu M, Ding J, Xu Y, Zhao X, Wang Y, Shan R, Zhu J, Xie J, Ge Q, Fan L, Ding Y, Xie Y, Zhang C, Li H, Wang H, Zhou H. Mass balance, metabolic disposition, and pharmacokinetics of a novel selective inhibitor of PI3Kδ [14C] SHC014748M in healthy Chinese subjects following oral administration. Cancer Chemother Pharmacol. 2023 Feb;91(2):143-156. doi: 10.1007/s00280-022-04493-5. Epub 2022 Dec 27. PMID: 36572783.
