MedKoo Cat#: 130219 | Name: aLPs-5g

Description:

WARNING: This product is for research use only, not for human or veterinary use.

aLPs-5g is a photoswitchable ligand targeting the vasopressin V2 receptor, allowing for a large degree of control over binding duration of the ligand to V2R. Furthermore, aLPs-5g shows promise as a key agent in the development of a treatment for autosomal dominant polycystic kidney disease (ADPKD).

Chemical Structure

aLPs-5g
aLPs-5g
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130219

Name: aLPs-5g

CAS#: N/A

Chemical Formula: C26H21ClN4O

Exact Mass: 440.1404

Molecular Weight: 440.93

Elemental Analysis: C, 70.82; H, 4.80; Cl, 8.04; N, 12.71; O, 3.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
aLPs-5g; aLPs 5g
IUPAC/Chemical Name
(E)-(5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-yl)(2-chloro-4-(p-tolyldiazenyl)phenyl)methanone
InChi Key
ZVWYOGGBJPAVTG-ZQHSETAFSA-N
InChi Code
InChI=1S/C26H21ClN4O/c1-18-8-10-20(11-9-18)28-29-21-12-13-23(24(27)15-21)26(32)31-17-22-6-4-14-30(22)16-19-5-2-3-7-25(19)31/h2-15H,16-17H2,1H3/b29-28+
SMILES Code
O=C(N1CC2=CC=CN2CC3=CC=CC=C13)C4=CC=C(/N=N/C5=CC=C(C)C=C5)C=C4Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 440.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Gu X, Yuan H, Zhao W, Sun N, Yan W, Jiang C, He Y, Liu H, Cheng J, Guo D. Optical-Controlled Kinetic Switch: Fine-Tuning of the Residence Time of an Antagonist Binding to the Vasopressin V2 Receptor in In Vitro, Ex Vivo, and In Vivo Models of ADPKD. J Med Chem. 2023 Jan 26;66(2):1454-1466. doi: 10.1021/acs.jmedchem.2c01625. Epub 2022 Dec 23. PMID: 36563185.