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MedKoo Cat#: 130206 | Name: Holanamine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Holanamine is an antileishmanial agent, specifically targeting Leishmania donovani, and was found to non-competitively inhibit LdToP1B. Docking studies have shown that the antileishmanial activity is achieved through hydrogen bonding and hydrophobic interactions of holanamine with the N-terminal and hinge region of the large subunit of LTop1B.

Chemical Structure

Holanamine
Holanamine
CAS#6869-29-0

Theoretical Analysis

MedKoo Cat#: 130206

Name: Holanamine

CAS#: 6869-29-0

Chemical Formula: C21H27NO2

Exact Mass: 325.2042

Molecular Weight: 325.45

Elemental Analysis: C, 77.50; H, 8.36; N, 4.30; O, 9.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Holanamine
IUPAC/Chemical Name
(3S,3aS,5aS,5bS,11aR,11bS,12R,13aR)-12-hydroxy-3,11a-dimethyl-3,3a,4,5,5a,5b,6,7,11a,11b,12,13-dodecahydro-9H-naphtho[2',1':4,5]indeno[1,7a-c]pyrrol-9-one
InChi Key
IRJULQGCGHNQDS-RSOCUBRASA-N
InChi Code
InChI=1S/C21H27NO2/c1-12-16-5-6-17-15-4-3-13-9-14(23)7-8-20(13,2)19(15)18(24)10-21(16,17)11-22-12/h7-9,11-12,15-19,24H,3-6,10H2,1-2H3/t12-,15-,16+,17-,18+,19+,20-,21-/m0/s1
SMILES Code
O=C1C=C[C@]2(C)[C@@]3([H])[C@H](O)C[C@]45C=N[C@@H](C)[C@@]4([H])CC[C@@]5([H])[C@]3([H])CCC2=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 325.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Goel N, Gupta VK, Garg A, Bhoumik A, Biswas R, Natarajan R, Majumder HK, Jaisankar P. Holanamine, a Steroidal Alkaloid from the Bark of Holarrhena pubescens Wall. ex G. Don Inhibits the Growth of Leishmania donovani by Targeting DNA Topoisomerase 1B. ACS Infect Dis. 2023 Jan 13;9(1):162-177. doi: 10.1021/acsinfecdis.2c00562. Epub 2022 Nov 23. PMID: 36417798.