HG381 is a potent and selective STING (stimulator of interferon genes) agonist, designed to activate the innate immune response via the cGAS-STING pathway. In preclinical studies, HG381 has demonstrated strong STING activation in human peripheral blood mononuclear cells (PBMCs), with an EC₅₀ in the low nanomolar range (~5–10 nM), leading to robust induction of type I interferons such as IFN-β and downstream cytokines like TNF-α and IL-6. In murine models, intratumoral administration of HG381 significantly enhanced antitumor immunity, resulting in tumor growth inhibition and increased infiltration of CD8⁺ T cells. Pharmacodynamic assays confirmed dose-dependent STING pathway activation, with upregulation of key markers such as p-TBK1 and IRF3.
MedKoo Cat#: 122822
Name: HG381
CAS#: 2361424-97-5
Chemical Formula: C21H26N6O4
Exact Mass: 426.2000
Molecular Weight: 426.48
Elemental Analysis: C, 59.14; H, 6.15; N, 19.71; O, 15.01
The following data is based on the product molecular weight 426.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
