3-Indoleacetonitrile | CAS#771-51-7 | antiviral agent

MedKoo Cat#: 130181 | Name: 3-Indoleacetonitrile

Description:

WARNING: This product is for research use only, not for human or veterinary use.

3-Indoleacetonitrile is an antiviral agent with the potential to treat SARS-CoV-2, influenza A, as well as interferes with the formation of various biofilms.

Chemical Structure

3-Indoleacetonitrile

CAS#771-51-7

Theoretical Analysis

MedKoo Cat#: 130181

Name: 3-Indoleacetonitrile

CAS#: 771-51-7

Chemical Formula: C10H8N2

Exact Mass: 156.0687

Molecular Weight: 156.19

Elemental Analysis: C, 76.90; H, 5.16; N, 17.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

3-Indoleacetonitrile; Indole-3-acetonitrile; 3Indoleacetonitrile; 3 Indoleacetonitrile

IUPAC/Chemical Name

2-(1H-indol-3-yl)acetonitrile

InChi Key

DMCPFOBLJMLSNX-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H8N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5H2

SMILES Code

N#CCC1=CNC2=C1C=CC=C2

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 156.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Hui X, Yu X, Huang K, Xu T, Cao L, Zhang Y, Zhao L, Zhao Y, Lv C, Feng S, Jiang Y, Liu L, Jin M. In vitro and in vivo effects of 3-indoleacetonitrile-A potential new broad-spectrum therapeutic agent for SARS-CoV-2 infection. Antiviral Res. 2023 Jan;209:105465. doi: 10.1016/j.antiviral.2022.105465. Epub 2022 Nov 17. PMID: 36402240; PMCID: PMC9671535. 2. Kashyap S, Sidhu H, Sharma P, Capalash N. 3-indoleacetonitrile attenuates biofilm formation and enhances sensitivity to imipenem in Acinetobacter baumannii. Pathog Dis. 2022 Aug 17;80(1):ftac029. doi: 10.1093/femspd/ftac029. PMID: 35867872. 3. Kira S, Miyamoto T, Tsuchiya S, Nakagomi H, Ihara T, Sawada N, Takeda M, Mitsui T. Potential Targets for Overactive Bladder in Older Men Based on Urinary Analysis of Metabolomics. Urol Int. 2022;106(7):672-678. doi: 10.1159/000518300. Epub 2021 Sep 16. PMID: 34569539. 4. Zhao X, Zhao L, Zhao Y, Huang K, Gong W, Yang Y, Zhao L, Xia X, Li Z, Sheng F, Du X, Jin M. 3-Indoleacetonitrile Is Highly Effective in Treating Influenza A Virus Infection In Vitro and In Vivo. Viruses. 2021 Jul 23;13(8):1433. doi: 10.3390/v13081433. PMID: 34452298; PMCID: PMC8402863. 5. Sethupathy S, Sathiyamoorthi E, Kim YG, Lee JH, Lee J. Antibiofilm and Antivirulence Properties of Indoles Against Serratia marcescens. Front Microbiol. 2020 Oct 30;11:584812. doi: 10.3389/fmicb.2020.584812. PMID: 33193228; PMCID: PMC7662412. 6. Kira S, Mitsui T, Miyamoto T, Ihara T, Nakagomi H, Hashimoto Y, Takamatsu H, Tanahashi M, Takeda M, Tsuchiya S, Sawada N, Takeda M. Urinary metabolites identified using metabolomic analysis as potential biomarkers of nocturia in elderly men. World J Urol. 2020 Oct;38(10):2563-2569. doi: 10.1007/s00345-019-03042-9. Epub 2019 Dec 3. PMID: 31797073. 7. He Y, Wang Y, Hu C, Sun X, Li Y, Xu N. Dynamic metabolic profiles of the marine macroalga Ulva prolifera during fragmentation-induced proliferation. PLoS One. 2019 May 15;14(5):e0214491. doi: 10.1371/journal.pone.0214491. PMID: 31091237; PMCID: PMC6519826. 8. Wang M, Xia W, Liu H, Liu F, Li H, Chang H, Sun J, Liu W, Sun X, Jiang Y, Liu H, Wu C, Pan X, Li Y, Rang W, Lu S, Xu S. Urinary metabolomics reveals novel interactions between metal exposure and amino acid metabolic stress during pregnancy. Toxicol Res (Camb). 2018 Jul 24;7(6):1164-1172. doi: 10.1039/c8tx00042e. PMID: 30510686; PMCID: PMC6220731.