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MedKoo Cat#: 130180 | Name: Sepimostat

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sepimostat is an inhibitor of serine protease, displaying potential neuroprotective effects as well as shows promise as a method of treating conditions related to/ a result of ASICs disfunction.

Chemical Structure

Sepimostat
CAS#103926-64-3

Theoretical Analysis

MedKoo Cat#: 130180

Name: Sepimostat

CAS#: 103926-64-3

Chemical Formula: C21H19N5O2

Exact Mass: 373.1539

Molecular Weight: 373.42

Elemental Analysis: C, 67.55; H, 5.13; N, 18.76; O, 8.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Sepimostat; 5ZFR16F4QQ
IUPAC/Chemical Name
6-carbamimidoylnaphthalen-2-yl 4-((4,5-dihydro-1H-imidazol-2-yl)amino)benzoate
InChi Key
QMRJOIUGPCVZPH-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H19N5O2/c22-19(23)16-2-1-15-12-18(8-5-14(15)11-16)28-20(27)13-3-6-17(7-4-13)26-21-24-9-10-25-21/h1-8,11-12H,9-10H2,(H3,22,23)(H2,24,25,26)
SMILES Code
O=C(OC1=CC=C2C=C(C(N)=N)C=CC2=C1)C3=CC=C(NC4=NCCN4)C=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 373.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Zhigulin AS, Tikhonov DB, Barygin OI. Mechanisms of acid-sensing ion channels inhibition by nafamostat, sepimostat and diminazene. Eur J Pharmacol. 2023 Jan 5;938:175394. doi: 10.1016/j.ejphar.2022.175394. Epub 2022 Nov 17. PMID: 36403685. 2. Adhikari N, Banerjee S, Baidya SK, Ghosh B, Jha T. Ligand-based quantitative structural assessments of SARS-CoV-2 3CLpro inhibitors: An analysis in light of structure-based multi-molecular modeling evidences. J Mol Struct. 2022 Mar 5;1251:132041. doi: 10.1016/j.molstruc.2021.132041. Epub 2021 Nov 29. PMID: 34866654; PMCID: PMC8627846. 3. Fuwa M, Kageyama M, Ohashi K, Sasaoka M, Sato R, Tanaka M, Tashiro K. Nafamostat and sepimostat identified as novel neuroprotective agents via NR2B N-methyl-D-aspartate receptor antagonism using a rat retinal excitotoxicity model. Sci Rep. 2019 Dec 31;9(1):20409. doi: 10.1038/s41598-019-56905-x. PMID: 31892740; PMCID: PMC6938488.

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PF-05212377

PF-05212377