BIBX-79 | CAS#175033-26-8 | 2,3-oxidosqualene cyclase inhibitor

MedKoo Cat#: 130175 | Name: BIBX-79

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BIBX-79 is a specific inhibitor of 2,3-oxidosqualene cyclase [EC 5.4.99.7]. The primary function of BIBX-79 is as an exploratory agent for the role of 2,3-oxidosqualene cyclase [EC 5.4.99.7] in maintaining intracellular cholesterol homeostasis.

Chemical Structure

BIBX-79

CAS#175033-26-8

Theoretical Analysis

MedKoo Cat#: 130175

Name: BIBX-79

CAS#: 175033-26-8

Chemical Formula: C23H29ClN2O

Exact Mass: 384.1968

Molecular Weight: 384.95

Elemental Analysis: C, 71.76; H, 7.59; Cl, 9.21; N, 7.28; O, 4.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

BIBX-79; BIBX-79; BIBX-79

IUPAC/Chemical Name

4-chloro-N-((1r,4r)-4-(4-((dimethylamino)methyl)phenyl)cyclohexyl)-N-methylbenzamide

InChi Key

WBNUHWUTAHSPER-XYWHTSSQSA-N

InChi Code

InChI=1S/C23H29ClN2O/c1-25(2)16-17-4-6-18(7-5-17)19-10-14-22(15-11-19)26(3)23(27)20-8-12-21(24)13-9-20/h4-9,12-13,19,22H,10-11,14-16H2,1-3H3/t19-,22-

SMILES Code

O=C(N([C@H]1CC[C@H](C2=CC=C(CN(C)C)C=C2)CC1)C)C3=CC=C(Cl)C=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 384.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Mark M, Muller P, Maier R, Eisele B. Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. J Lipid Res. 1996 Jan;37(1):148-58. PMID: 8820110. 2. Duniec-Dmuchowski Z, Fang HL, Strom SC, Ellis E, Runge-Morris M, Kocarek TA. Human pregnane X receptor activation and CYP3A4/CYP2B6 induction by 2,3-oxidosqualene:lanosterol cyclase inhibition. Drug Metab Dispos. 2009 Apr;37(4):900-8. doi: 10.1124/dmd.108.025130. Epub 2009 Jan 21. PMID: 19158313; PMCID: PMC2680536. 3. Duniec-Dmuchowski Z, Fang HL, Strom SC, Ellis E, Runge-Morris M, Kocarek TA. Human pregnane X receptor activation and CYP3A4/CYP2B6 induction by 2,3-oxidosqualene:lanosterol cyclase inhibition. Drug Metab Dispos. 2009 Apr;37(4):900-8. doi: 10.1124/dmd.108.025130. Epub 2009 Jan 21. PMID: 19158313; PMCID: PMC2680536.