MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 130159 | Name: TDI-11861

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TDI-11861 is a sAC/ADCY10 inhibitor and has promise for use as a male contraceptive, which is partially attributed to its slow dissociation rates. TDI-11861 has been shown to inhibit sperm motility in vivo. TDI-11861 functions by binding sAC protein and inhibiting the in vitro activity of adenylyl cyclase activity of purified sAC protein.

Chemical Structure

TDI-11861
TDI-11861
CAS#2857049-72-8

Theoretical Analysis

MedKoo Cat#: 130159

Name: TDI-11861

CAS#: 2857049-72-8

Chemical Formula: C22H25ClF2N6O3

Exact Mass: 494.1645

Molecular Weight: 494.93

Elemental Analysis: C, 53.39; H, 5.09; Cl, 7.16; F, 7.68; N, 16.98; O, 9.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
TDI-11861; TDI11861; TDI 11861
IUPAC/Chemical Name
(R)-(4-(2-(2-((3-(2-amino-6-chloropyrimidin-4-yl)-1-(difluoromethyl)-1H-pyrazol-4-yl)methyl)phenoxy)ethyl)morpholin-3-yl)methanol
InChi Key
XVGSKZXXLKUEIO-MRXNPFEDSA-N
InChi Code
InChI=1S/C22H25ClF2N6O3/c23-19-10-17(27-22(26)28-19)20-15(11-31(29-20)21(24)25)9-14-3-1-2-4-18(14)34-8-6-30-5-7-33-13-16(30)12-32/h1-4,10-11,16,21,32H,5-9,12-13H2,(H2,26,27,28)/t16-/m1/s1
SMILES Code
OC[C@H]1N(CCOC2=CC=CC=C2CC3=CN(C(F)F)N=C3C4=NC(N)=NC(Cl)=C4)CCOC1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 494.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Balbach M, Rossetti T, Ferreira J, Ghanem L, Ritagliati C, Myers RW, Huggins DJ, Steegborn C, Miranda IC, Meinke PT, Buck J, Levin LR. On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nat Commun. 2023 Feb 14;14(1):637. doi: 10.1038/s41467-023-36119-6. PMID: 36788210; PMCID: PMC9929232. 2. Rossetti T, Ferreira J, Ghanem L, Buck H, Steegborn C, Myers RW, Meinke PT, Levin LR, Buck J. Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential. Front Physiol. 2022 Sep 28;13:1013845. doi: 10.3389/fphys.2022.1013845. Erratum in: Front Physiol. 2022 Nov 21;13:1092217. PMID: 36246105; PMCID: PMC9554468.