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MedKoo Cat#: 130154 | Name: THTMP

Description:

WARNING: This product is for research use only, not for human or veterinary use.

THTMP is a potential anticancer agent for the treatment of glioblastoma, increasing glioblastoma cell death. THTMP was found to induce cell death/anti-proliferative activity, through affecting cell cycle arrest and intrinsic apoptosis signaling.

Chemical Structure

THTMP
THTMP
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130154

Name: THTMP

CAS#: N/A

Chemical Formula: C23H23NO

Exact Mass: 329.1780

Molecular Weight: 329.44

Elemental Analysis: C, 83.85; H, 7.04; N, 4.25; O, 4.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
THTMP
IUPAC/Chemical Name
2-((3,4-dihydroquinolin-1(2H)-yl)(p-tolyl)methyl)phenol
InChi Key
JEVBIIVNLBNALY-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H23NO/c1-17-12-14-19(15-13-17)23(20-9-3-5-11-22(20)25)24-16-6-8-18-7-2-4-10-21(18)24/h2-5,7,9-15,23,25H,6,8,16H2,1H3
SMILES Code
OC1=CC=CC=C1C(N2CCCC3=C2C=CC=C3)C4=CC=C(C)C=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 329.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Doan P, Musa A, Candeias NR, Emmert-Streib F, Yli-Harja O, Kandhavelu M. Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway. Front Pharmacol. 2019 Apr 2;10:330. doi: 10.3389/fphar.2019.00330. PMID: 31001122; PMCID: PMC6454069. 2. Doan P, Nguyen P, Murugesan A, Candeias NR, Yli-Harja O, Kandhavelu M. Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity. Cells. 2021 Aug 3;10(8):1975. doi: 10.3390/cells10081975. PMID: 34440745; PMCID: PMC8393831. 3. Palanivel S, Yli-Harja O, Kandhavelu M. Molecular interaction study of novel indoline derivatives with EGFR-kinase domain using multiple computational analysis. J Biomol Struct Dyn. 2022 Oct;40(16):7545-7554. doi: 10.1080/07391102.2021.1900917. Epub 2021 Mar 22. PMID: 33749517. 4. Doan P, Musa A, Murugesan A, Sipilä V, Candeias NR, Emmert-Streib F, Ruusuvuori P, Granberg K, Yli-Harja O, Kandhavelu M. Glioblastoma Multiforme Stem Cell Cycle Arrest by Alkylaminophenol Through the Modulation of EGFR and CSC Signaling Pathways. Cells. 2020 Mar 10;9(3):681. doi: 10.3390/cells9030681. PMID: 32164385; PMCID: PMC7140667. 5. Palanivel S, Yli-Harja O, Kandhavelu M. Alkylamino Phenol Derivative Induces Apoptosis by Inhibiting EGFR Signaling Pathway in Breast Cancer Cells. Anticancer Agents Med Chem. 2020;20(7):809-819. doi: 10.2174/1871520620666200213101407. PMID: 32053080.