EC/11770 | CAS#N/A | leucyl-tRNA synthetase inhibitor

MedKoo Cat#: 130148 | Name: EC/11770

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EC/11770 is a leucyl-tRNA synthetase inhibitor, with potential for use as a treatment for tuberculosis, as well as M. abscessus and M. avium complexes. EC/11770 targets the editing domain of LeuRS to attain its anti-NTM activity.

Chemical Structure

EC/11770

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130148

Name: EC/11770

CAS#: N/A

Chemical Formula: C12H17BBrNO4

Exact Mass: 329.0434

Molecular Weight: 329.99

Elemental Analysis: C, 43.68; H, 5.19; B, 3.28; Br, 24.21; N, 4.24; O, 19.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

EC/11770; EC-11770; EC11770; EC 11770; Benzoxaborole EC/11770

IUPAC/Chemical Name

(S)-3-(aminomethyl)-4-bromo-7-(2-hydroxy-2-methylpropoxy)benzo[c][1,2]oxaborol-1(3H)-ol

InChi Key

YYGLYAMJRNPPAT-SECBINFHSA-N

InChi Code

InChI=1S/C12H17BBrNO4/c1-12(2,16)6-18-8-4-3-7(14)10-9(5-15)19-13(17)11(8)10/h3-4,9,16-17H,5-6,15H2,1-2H3/t9-/m1/s1

SMILES Code

OB1O[C@H](CN)C2=C(Br)C=CC(OCC(C)(O)C)=C12

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 329.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Ganapathy US, Del Rio RG, Cacho-Izquierdo M, Ortega F, Lelièvre J, Barros-Aguirre D, Lindman M, Dartois V, Gengenbacher M, Dick T. A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Anti-Mycobacterial Activity. Antimicrob Agents Chemother. 2021 Feb 8;65(5):e02420-20. doi: 10.1128/AAC.02420-20. Epub ahead of print. PMID: 33558292; PMCID: PMC8092876.