Anti-AD agent C10 is a dual AChE and MAO-B inhibitor (AChE: IC50 = 0.58 ± 0.05 μM; MAO-B: IC50 = 0.41 ± 0.04 μM) for the treatment of Alzheimer's disease. The compound C10 displayed binding capabilities at both the catalytic anionic site and peripheral anionic site of AChE, along with increased protection against mitochondrial dysfunction, and reduced amyloid aggregation due to AChE, suggesting that it demonstrates significant potential as a treatment for Alzheimer's disease.
MedKoo Cat#: 130139
Name: Anti-AD agent C10
CAS#: N/A
Chemical Formula: C30H26F3NO3
Exact Mass: 505.1865
Molecular Weight: 505.54
Elemental Analysis: C, 71.28; H, 5.18; F, 11.27; N, 2.77; O, 9.49
The following data is based on the product molecular weight 505.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
