MedKoo Cat#: 130131 | Name: SAS-0132

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SAS-0132 is a modulator/antagonist of sigma2R/TMEM97 and has potential for treating TBIs, Alzheimer's disease, and neuropathic pain.

Chemical Structure

SAS-0132
SAS-0132
CAS# 2095551-89-4

Theoretical Analysis

MedKoo Cat#: 130131

Name: SAS-0132

CAS#: 2095551-89-4

Chemical Formula: C24H29N3O2

Exact Mass: 391.2260

Molecular Weight: 391.52

Elemental Analysis: C, 73.63; H, 7.47; N, 10.73; O, 8.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SAS-0132; SAS0132; SAS 0132
IUPAC/Chemical Name
Benzyl (1R,5S)-8-(4-methylpiperazin-1-yl)-1,3,4,5-tetrahydro-2H-1,5-methanobenzo[c]azepine-2-carboxylate
InChi Key
CQQWIHMDQBNBBE-WMZHIEFXSA-N
InChi Code
InChI=1S/C24H29N3O2/c1-25-11-13-26(14-12-25)20-7-8-21-19-9-10-27(23(15-19)22(21)16-20)24(28)29-17-18-5-3-2-4-6-18/h2-8,16,19,23H,9-15,17H2,1H3/t19-,23+/m0/s1
SMILES Code
O=C(N1[C@@](C2)([H])C3=CC(N4CCN(C)CC4)=CC=C3[C@@]2([H])CC1)OCC5=CC=CC=C5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 391.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Vázquez-Rosa E, Watson MR, Sahn JJ, Hodges TR, Schroeder RE, Cintrón-Pérez CJ, Shin MK, Yin TC, Emery JL, Martin SF, Liebl DJ, Pieper AA. Neuroprotective Efficacy of a Sigma 2 Receptor/TMEM97 Modulator (DKR-1677) after Traumatic Brain Injury. ACS Chem Neurosci. 2019 Mar 20;10(3):1595-1602. doi: 10.1021/acschemneuro.8b00543. Epub 2018 Dec 3. PMID: 30421909; PMCID: PMC6862717. 2. Sahn JJ, Mejia GL, Ray PR, Martin SF, Price TJ. Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice. ACS Chem Neurosci. 2017 Aug 16;8(8):1801-1811. doi: 10.1021/acschemneuro.7b00200. Epub 2017 Jul 13. PMID: 28644012; PMCID: PMC5715471. 3. Yi B, Sahn JJ, Ardestani PM, Evans AK, Scott LL, Chan JZ, Iyer S, Crisp A, Zuniga G, Pierce JT, Martin SF, Shamloo M. Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease. J Neurochem. 2017 Feb;140(4):561-575. doi: 10.1111/jnc.13917. PMID: 27926996; PMCID: PMC5312682.