MRK-990 is a PRMT9 and PRMT5 dual inhibitor. MRK-990 inhibits PRMT9 with IC50 = 10 nM and PRMT5 with IC50 = 30 nM in a radioactivity based methyltranserase assay. In an in-cell western assay, MRK-990 inhibits the methylation of SAP145 (PRMT9) with IC50 = 145 nM, and dimethylarginine (PRMT5) with IC50 = 519 nM. MRK-990-NC is a closely related negative control with IC50 > 10 micromolar.
MedKoo Cat#: 130124
Name: MRK-990
CAS#: N/A
Chemical Formula: C26H38N6O3S
Exact Mass: 514.2726
Molecular Weight: 514.69
Elemental Analysis: C, 60.67; H, 7.44; N, 16.33; O, 9.33; S, 6.23
The following data is based on the product molecular weight 514.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
