MedKoo Cat#: 130113 | Name: DNs-HMRG

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DNs-HMRG is a highly sensitive fluorescent glutathione (GSH) probe with good cell permeability, regulated by both intramolecular spirocyclization and photo-induced electron transfer. DNs-HMRG has potential for tumor detection, and due to the fact that GSH is present in higher levels in tumors, has been successfully used for detection of small tumors in mice.

Chemical Structure

DNs-HMRG
DNs-HMRG
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130113

Name: DNs-HMRG

CAS#: N/A

Chemical Formula: C26H18N4O8S

Exact Mass: 546.0845

Molecular Weight: 546.51

Elemental Analysis: C, 57.14; H, 3.32; N, 10.25; O, 23.42; S, 5.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DNs-HMRG; DNs HMRG
IUPAC/Chemical Name
N-(3'-Amino-3H-spiro[isobenzofuran-1,9'-xanthen]-6'-yl)-2,4-dinitrobenzenesulfonamide
InChi Key
SPKAMQGTNRRGEL-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H18N4O8S/c27-16-5-8-20-23(11-16)38-24-12-17(6-9-21(24)26(20)19-4-2-1-3-15(19)14-37-26)28-39(35,36)25-10-7-18(29(31)32)13-22(25)30(33)34/h1-13,28H,14,27H2
SMILES Code
O=S(C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O)(NC2=CC3=C(C4(C5=C(O3)C=C(N)C=C5)OCC6=C4C=CC=C6)C=C2)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 546.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Yoshida M, Kamiya M, Yamasoba T, Urano Y. A highly sensitive, cell-membrane-permeable fluorescent probe for glutathione. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4363-4366. doi: 10.1016/j.bmcl.2014.08.033. Epub 2014 Aug 20. PMID: 25176192. 2.