MedKoo Cat#: 130110 | Name: 5-Carboxystrictosidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

5-Carboxystrictosidine, which is found in the medicinal Mappianthus iodoides Hand.-Mazz. root, is a mitochondrial KATP channel activator with evidence suggestive of its potential use to prevent I/R injury of the heart. It was suggested the protective effects may be a result of antioxidant and decreased apoptotic effects achieved through the opening of mitochondrial KATP channels.

Chemical Structure

5-Carboxystrictosidine
5-Carboxystrictosidine
CAS#34371-47-6

Theoretical Analysis

MedKoo Cat#: 130110

Name: 5-Carboxystrictosidine

CAS#: 34371-47-6

Chemical Formula: C28H34N2O11

Exact Mass: 574.2163

Molecular Weight: 574.58

Elemental Analysis: C, 58.53; H, 5.96; N, 4.88; O, 30.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
5-Carboxystrictosidine; 5 Carboxystrictosidine; 5Carboxystrictosidine; 5(S)-5-carboxystrictosidine; (5S)-5-carboxystrictosidine
IUPAC/Chemical Name
(1S,3S)-1-(((2S,3R,4S)-5-(methoxycarbonyl)-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-vinyl-3,4-dihydro-2H-pyran-4-yl)methyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
InChi Key
LHKZIVMTXZLOTP-RMKGEEGASA-N
InChi Code
InChI=1S/C28H34N2O11/c1-3-12-14(8-18-21-15(9-19(29-18)25(35)36)13-6-4-5-7-17(13)30-21)16(26(37)38-2)11-39-27(12)41-28-24(34)23(33)22(32)20(10-31)40-28/h3-7,11-12,14,18-20,22-24,27-34H,1,8-10H2,2H3,(H,35,36)/t12-,14+,18+,19+,20-,22-,23+,24-,27+,28+/m1/s1
SMILES Code
O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]2OC=C(C(OC)=O)[C@@H](C[C@H]3C4=C(C5=CC=CC=C5N4)C[C@@H](C(O)=O)N3)[C@H]2C=C)[C@@H]1O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 574.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Han Y, Li C, Zhang P, Yang X, Min J, Wu Q, Xie Y, Jin D, Wang Z, Shao F, Quan H. Protective effects of 5(S)-5-carboxystrictosidine on myocardial ischemia-reperfusion injury through activation of mitochondrial KATP channels. Eur J Pharmacol. 2022 Apr 5;920:174811. doi: 10.1016/j.ejphar.2022.174811. Epub 2022 Feb 17. PMID: 35182546.