RA-1 is a proteasome inhibitor with potential as a treatment for cervical cancer. It was suggested that RA-1 inhibits the proteasome due to the carbonyl group of its oxopiperidine moiety being susceptible to nucleophilic attack by the γ-hydroxythreonine side chain within the catalytic sites of the proteasome. RA-1 has also shown to promote apoptosis of cervical cancer cells containing HPV.
MedKoo Cat#: 130092
Name: RA-1
CAS#: N/A
Chemical Formula: C29H22Cl4N2O4
Exact Mass: 602.0334
Molecular Weight: 604.31
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 57.64; H, 3.67; Cl, 23.46; N, 4.64; O, 10.59
The following data is based on the product molecular weight 604.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
