KS-19 is a KRAS G12C inhibitor. KS-19 has been shown to exhibit higher antiproliferative activity (IC50 = 0.66 μM) as compared to ARS-1620 (1.32 μM), decrease KRAS G12C-GTP and pErk levels, and was able to suppress NCI-H358 tumor growth to a higher degree.
MedKoo Cat#: 130080
Name: KS-19
CAS#: N/A
Chemical Formula: C24H18Cl2FN5O5
Exact Mass: 545.0669
Molecular Weight: 546.34
Elemental Analysis: C, 52.76; H, 3.32; Cl, 12.98; F, 3.48; N, 12.82; O, 14.64
The following data is based on the product molecular weight 546.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
