MedKoo Cat#: 130075 | Name: SIL-14

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SIL-14 is a STAT3 inhibitor, inhibiting the phosphorylation of STAT3, which plays a key role in cancer regulation. SIL-14 has potential to treat gastric cancer by inhibiting the formation of colonies and migration of MGC803 gastric cancer cells, along with inducing apoptosis of MGC803.

Chemical Structure

SIL-14
SIL-14
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130075

Name: SIL-14

CAS#: N/A

Chemical Formula: C32H31N3O7S

Exact Mass: 601.1883

Molecular Weight: 601.67

Elemental Analysis: C, 63.88; H, 5.19; N, 6.98; O, 18.61; S, 5.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SIL-14; SIL14; SIL 14
IUPAC/Chemical Name
2-((4-(4-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)piperidine-1-carbonyl)-3-methylphenyl)amino)-2-oxoethyl 4-methylbenzenesulfonate
InChi Key
HKAKQUALPHAPRM-UHFFFAOYSA-N
InChi Code
InChI=1S/C32H31N3O7S/c1-20-7-10-24(11-8-20)43(40,41)42-19-30(37)34-23-9-12-25(21(2)17-23)32(39)35-15-13-22(14-16-35)33-28-18-29(36)26-5-3-4-6-27(26)31(28)38/h3-12,17-18,22,33H,13-16,19H2,1-2H3,(H,34,37)
SMILES Code
O=S(C1=CC=C(C)C=C1)(OCC(NC2=CC=C(C(N3CCC(NC(C4=O)=CC(C5=C4C=CC=C5)=O)CC3)=O)C(C)=C2)=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 601.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Li H, Cai M, Cao F, Yu D, Yang J, Yu W, Chu C, Guan X, Qin JJ, Dong J. S3I-201 derivative incorporating naphthoquinone unit as effective STAT3 inhibitors: Design, synthesis and anti-gastric cancer evaluation. Bioorg Med Chem. 2022 Oct 1;71:116941. doi: 10.1016/j.bmc.2022.116941. Epub 2022 Jul 19. PMID: 35944386.