PRT-543 is a selective oral PRMT5 inhibitor with a phase 1 clinical trial currently ongoing, testing its effectiveness as a treatment for solid tumors and hematologic malignancies. PRT-543 functions by selectively binding to the PRMT5 substrate recognition site, inhibiting methyltransferase, ultimately increasing the expression of anti-proliferative genes or decreasing expression of proliferative genes, which in turn can be used to prevent proliferation of cancer cells.
MedKoo Cat#: 130073
Name: PRT-543
CAS#: 1989620-03-2
Chemical Formula: C17H17ClN4O4
Exact Mass: 376.0938
Molecular Weight: 376.80
Elemental Analysis: C, 54.19; H, 4.55; Cl, 9.41; N, 14.87; O, 16.98
The following data is based on the product molecular weight 376.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
