MedKoo Cat#: 130040 | Name: Nimucitinib
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nimucitinib is a Janus kinase (JAK) inhibitor.

Chemical Structure

Nimucitinib
CAS#2740557-24-6

Theoretical Analysis

MedKoo Cat#: 130040

Name: Nimucitinib

CAS#: 2740557-24-6

Chemical Formula: C25H26F2N6O2

Exact Mass: 480.2085

Molecular Weight: 480.52

Elemental Analysis: C, 62.49; H, 5.45; F, 7.91; N, 17.49; O, 6.66

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Nimucitinib
IUPAC/Chemical Name
(S)-4-((3,5-difluorobenzyl)amino)-6-((3-(piperidine-3-carboxamido)phenyl)amino)nicotinamide
InChi Key
FDQSOYXLRVBMGA-INIZCTEOSA-N
InChi Code
InChI=1S/C25H26F2N6O2/c26-17-7-15(8-18(27)9-17)12-30-22-11-23(31-14-21(22)24(28)34)32-19-4-1-5-20(10-19)33-25(35)16-3-2-6-29-13-16/h1,4-5,7-11,14,16,29H,2-3,6,12-13H2,(H2,28,34)(H,33,35)(H2,30,31,32)/t16-/m0/s1
SMILES Code
[H][C@]1(C(NC2=CC=CC(NC3=NC=C(C(N)=O)C(NCC4=CC(F)=CC(F)=C4)=C3)=C2)=O)CCCNC1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Janus kinases are non-receptor tyrosine kinases that interact with the proximal region of cytokine receptors. Janus kinases are vital in promoting cell growth, survival, and differentiation, especially for immune cells and hematopoietic cells. Janus kinase inhibitors have recently been used as an alternate treatment for inflammatory diseases by inhibiting cytokine activity/secretion. 1. Ghoreschi K, Laurence A, O'Shea JJ. Janus kinases in immune cell signaling. Immunol Rev. 2009 Mar;228(1):273-87. doi: 10.1111/j.1600-065X.2008.00754.x. PMID: 19290934; PMCID: PMC2782696. 2. Lin CM, Cooles FA, Isaacs JD. Basic Mechanisms of JAK Inhibition. Mediterr J Rheumatol. 2020 Jun 11;31(Suppl 1):100-104. doi: 10.31138/mjr.31.1.100. PMID: 32676567; PMCID: PMC7361186. 3. Yamaoka K, Saharinen P, Pesu M, Holt VE 3rd, Silvennoinen O, O'Shea JJ. The Janus kinases (Jaks). Genome Biol. 2004;5(12):253. doi: 10.1186/gb-2004-5-12-253. Epub 2004 Nov 30. PMID: 15575979; PMCID: PMC545791.

Preparing Stock Solutions

The following data is based on the product molecular weight 480.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL