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MedKoo Cat#: 122634 | Name: DC-CPin734

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DC-CPin734 is a CBP/P300 BRD inhibitor.

Chemical Structure

DC-CPin734
DC-CPin734
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 122634

Name: DC-CPin734

CAS#: N/A

Chemical Formula: C21H21N5O2

Exact Mass: 375.1700

Molecular Weight: 375.43

Elemental Analysis: C, 67.18; H, 5.64; N, 18.65; O, 8.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
DC-CPin734; DCCPin734; DC CPin734
IUPAC/Chemical Name
6-(4-(1H-pyrazol-5-yl)benzamido)-N-methyl-3,4-dihydroquinoline-1(2H)-carboxamide
InChi Key
QHHJMGIXHASDOF-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H21N5O2/c1-22-21(28)26-12-2-3-16-13-17(8-9-19(16)26)24-20(27)15-6-4-14(5-7-15)18-10-11-23-25-18/h4-11,13H,2-3,12H2,1H3,(H,22,28)(H,23,25)(H,24,27)
SMILES Code
CNC(N1CCCC2=C1C=CC(NC(C3=CC=C(C4=CC=NN4)C=C3)=O)=C2)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 375.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Bi X, Chen Y, Sun Z, Lu W, Xu P, Lu T, Ding H, Zhang N, Jiang H, Chen K, Zhou B, Luo C. Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127480. doi: 10.1016/j.bmcl.2020.127480. Epub 2020 Aug 31. PMID: 32882416. Yellapu, N.K., Ly, T., Sardiu, M.E. et al. Synergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer. BMC Cancer 22, 627 (2022).