Gemlapodect | CAS#1380329-87-2 | PDE10A inhibitor

MedKoo Cat#: 130030 | Name: Gemlapodect

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Gemlapodect is a phosphodiesterase 10A (PDE10A) inhibitor currently undergoing clinical trials for use as a treatment for Tourette's Syndrome by modulating the signaling of D2 receptors. PDE10A is highly expressed in striatal medium spiny neurons, with inhibition leading to behavioral and antipsychotic effects.

Chemical Structure

Gemlapodect

CAS#1380329-87-2

Theoretical Analysis

MedKoo Cat#: 130030

Name: Gemlapodect

CAS#: 1380329-87-2

Chemical Formula: C22H21N7O3

Exact Mass: 431.1706

Molecular Weight: 431.46

Elemental Analysis: C, 61.24; H, 4.91; N, 22.73; O, 11.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Gemlapodect

IUPAC/Chemical Name

1-methyl-4-[(morpholin-4-yl)carbonyl]-N-(2- phenyl[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-5- carboxamide

InChi Key

MMCSMWHWVGGCGL-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H21N7O3/c1-27-19(17(14-23-27)22(31)28-9-11-32-12-10-28)21(30)24-16-7-8-29-18(13-16)25-20(26-29)15-5-3-2-4-6-15/h2-8,13-14H,9-12H2,1H3,(H,24,30)

SMILES Code

O=C(C1=C(C(N2CCOCC2)=O)C=NN1C)NC3=CC4=NC(C5=CC=CC=C5)=NN4C=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 431.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Menniti FS, Chappie TA, Schmidt CJ. PDE10A Inhibitors-Clinical Failure or Window Into Antipsychotic Drug Action? Front Neurosci. 2021 Jan 20;14:600178. doi: 10.3389/fnins.2020.600178. PMID: 33551724; PMCID: PMC7855852.