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MedKoo Cat#: 556173 | Name: 246C10

Description:

WARNING: This product is for research use only, not for human or veterinary use.

246C10 is an ionizable lipid. 246C10 can be formulated into lipid nanoparticles (LNPs). The lipid nanoparticle formulations can be used for mRNA delivery.

Chemical Structure

246C10
246C10
CAS#2635329-26-7

Theoretical Analysis

MedKoo Cat#: 556173

Name: 246C10

CAS#: 2635329-26-7

Chemical Formula: C58H120N4O4

Exact Mass: 936.9310

Molecular Weight: 937.62

Elemental Analysis: C, 74.30; H, 12.90; N, 5.98; O, 6.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
246C10; 246C-10; 246C 10;
IUPAC/Chemical Name
1,1',1'',1'''-((piperazine-1,4-diylbis(propane-3,1-diyl))bis(azanetriyl))tetrakis(dodecan-2-ol)
InChi Key
NLIUSFYZNWSAEC-UHFFFAOYSA-N
InChi Code
InChI=1S/C58H120N4O4/c1-5-9-13-17-21-25-29-33-39-55(63)51-61(52-56(64)40-34-30-26-22-18-14-10-6-2)45-37-43-59-47-49-60(50-48-59)44-38-46-62(53-57(65)41-35-31-27-23-19-15-11-7-3)54-58(66)42-36-32-28-24-20-16-12-8-4/h55-58,63-66H,5-54H2,1-4H3
SMILES Code
CCCCCCCCCCC(O)CN(CC(O)CCCCCCCCCC)CCCN1CCN(CCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)CC1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Ionizable lipid nanoparticles (LNPs) have been widely used for in vivo delivery of RNA therapeutics into the liver.

Preparing Stock Solutions

The following data is based on the product molecular weight 937.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Kim M, Jeong M, Hur S, Cho Y, Park J, Jung H, Seo Y, Woo HA, Nam KT, Lee K, Lee H. Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver. Sci Adv. 2021 Feb 26;7(9):eabf4398. doi: 10.1126/sciadv.abf4398. PMID: 33637537; PMCID: PMC7909888.