MAO-A/5-HT2AR Inhibitor I14 is a dual MAO-A and 5-HT2AR inhibitor with improved antidepressant activity. The MAO-A/5-HT2AR Inhibitor I14 has been found to be able to occupy the active cavity of 5-HT2AR and MAO-A with multiple hydrogen bonding forces and π–π stacking interaction. It has also led to a reduction in the expression of 5-HT2AR in the brain tissue of mice through the promotion of interstitial 5-HT levels, which ultimately increases the efficiency of the antidepressant effect.
MedKoo Cat#: 130002
Name: MAO-A/5-HT2AR Inhibitor I14
CAS#: N/A
Chemical Formula: C31H30FN3O2
Exact Mass: 495.2322
Molecular Weight: 495.60
Elemental Analysis: C, 75.13; H, 6.10; F, 3.83; N, 8.48; O, 6.46
The following data is based on the product molecular weight 495.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
