CZ-48, also known as Sulfo-ara-F-NMN, is a cell-permeant mimetic of NMN. CZ-48 activated SARM1 in vitro and in cellulo to cyclize NAD and produce a Ca2+ messenger, cADPR, with similar efficiency as NMN. CZ-48 activated SARM1 via a conformational change of the auto-inhibitory domain and dimerization of its catalytic domain. CZ-48 acted selectively, activating SARM1 but inhibiting CD38. In SARM1-overexpressing cells, CZ-48 elevated cADPR, depleted NAD and ATP, and induced non-apoptotic death. CZ-48 is a specific modulator of SARM1 functions in cells.
MedKoo Cat#: 556171
Name: CZ-48
CAS#: 1374663-29-2
Chemical Formula: C11H14FN2O6PS
Exact Mass: 352.0294
Molecular Weight: 352.27
Elemental Analysis: C, 37.51; H, 4.01; F, 5.39; N, 7.95; O, 27.25; P, 8.79; S, 9.10
The following data is based on the product molecular weight 352.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
