2'-Fluoro-2'-deoxyadenosine | CAS#64183-27-3 | Nucleosides

MedKoo Cat#: 122476 | Name: 2'-Fluoro-2'-deoxyadenosine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

2'-Fluoro-2'-deoxyadenosine

Chemical Structure

2'-Fluoro-2'-deoxyadenosine

CAS#64183-27-3

Theoretical Analysis

MedKoo Cat#: 122476

Name: 2'-Fluoro-2'-deoxyadenosine

CAS#: 64183-27-3

Chemical Formula: C10H12FN5O3

Exact Mass: 269.0924

Molecular Weight: 269.24

Elemental Analysis: C, 44.61; H, 4.49; F, 7.06; N, 26.01; O, 17.83

Price and Availability

Size	Price	Availability
1g	USD 250.00	2 Weeks
2g	USD 400.00	2 Weeks
5g	USD 750.00	2 Weeks

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Related CAS #

No Data

Synonym

2'-Fluoro-2'-deoxyadenosine; 64183-27-3; 2'-Deoxy-2'-fluoroadenosine; Adenosine, 2'-deoxy-2'-fluoro-

IUPAC/Chemical Name

(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

InChi Key

ZGYYPTJWJBEXBC-QYYRPYCUSA-N

InChi Code

InChI=1S/C10H12FN5O3/c11-5-7(18)4(1-17)19-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17-18H,1H2,(H2,12,13,14)/t4-,5-,7-,10-/m1/s1

SMILES Code

O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC3=C(N)N=CN=C23)[C@@H]1F

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 269.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hirashima S, Sugiyama H, Park S. Characterization of 2-Fluoro-2'-deoxyadenosine in Duplex, G-Quadruplex and i-Motif. Chembiochem. 2022 Jun 20;23(12):e202200222. doi: 10.1002/cbic.202200222. Epub 2022 May 9. PMID: 35438834. 2: Yoo YJ, Choi KH, Kim BK, Choi SS, Kim ES. Isolation and Characterization of Engineered Nucleoside Deoxyribosyltransferase with Enhanced Activity Toward 2'-Fluoro-2'-Deoxynucleoside. J Microbiol Biotechnol. 2022 Aug 28;32(8):1041-1046. doi: 10.4014/jmb.2204.04041. Epub 2022 Jun 15. PMID: 35791073; PMCID: PMC9628941. 3: Parker WB, Allan PW, Hassan AE, Secrist JA 3rd, Sorscher EJ, Waud WR. Antitumor activity of 2-fluoro-2'-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase. Cancer Gene Ther. 2003 Jan;10(1):23-9. doi: 10.1038/sj.cgt.7700520. PMID: 12489025.