MC-DM1 is a Maytansine derative and a DM1 molecule with an reactive linker MC. MC-DM1 is a useful precursor to make drug antibody congjuate (ADC) such as HER2-Targeting Affibody-DM1 Drug Conjugates. The resulting affibody drug conjugates were potent cytotoxic molecules for human cells over-expressing HER2, with sub-nanomolar IC50-values similar to trastuzumab emtansine, and did not affect cells with low HER2 expression. A biodistribution study of a radiolabeled version of (ZHER2:2891)2-ABD-MC-DM1, showed that it was taken up by the tumor. The major site of off-target uptake was the kidneys and to some extent the liver. (ZHER2:2891)2-ABD-MC-DM1 was found to have a half-life in circulation of 14 h. The compound was tolerated well by mice at 8.5 mg/kg and was shown to extend survival of mice bearing HER2 over-expressing tumors.
MedKoo Cat#: 408188
Name: MC-DM1
CAS#: 1375089-56-7
Chemical Formula: C42H55ClN4O12
Exact Mass: 842.3505
Molecular Weight: 843.37
Elemental Analysis: C, 59.82; H, 6.57; Cl, 4.20; N, 6.64; O, 22.76
The following data is based on the product molecular weight 843.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
