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MedKoo Cat#: 122439 | Name: DS-9300

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DS-9300 is a A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor. DS-9300 demonstrated potent antitumor effects in a castrated VCaP xenograft mouse model without significant body weight loss

Chemical Structure

DS-9300
DS-9300
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 122439

Name: DS-9300

CAS#: N/A

Chemical Formula: C25H26F3N5O3

Exact Mass: 501.1988

Molecular Weight: 501.51

Elemental Analysis: C, 59.87; H, 5.23; F, 11.36; N, 13.96; O, 9.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DS-9300, DS 9300, DS9300
IUPAC/Chemical Name
(2R,4R)-1-(4,4-difluoro-1-(4-methoxyphenyl)cyclohexane-1-carbonyl)-4-fluoro-N-(1H-pyrazolo[4,3-b]pyridin-5-yl)pyrrolidine-2-carboxamide
InChi Key
UCKDTCZSOLMOMQ-OXQOHEQNSA-N
InChi Code
InChI=1S/C25H26F3N5O3/c1-36-17-4-2-15(3-5-17)24(8-10-25(27,28)11-9-24)23(35)33-14-16(26)12-20(33)22(34)31-21-7-6-18-19(30-21)13-29-32-18/h2-7,13,16,20H,8-12,14H2,1H3,(H,29,32)(H,30,31,34)/t16-,20-/m1/s1
SMILES Code
O=C(NC1=CC=C(NN=C2)C2=N1)[C@@H]3N(C(C4(C5=CC=C(OC)C=C5)CCC(F)(F)CC4)=O)C[C@H](F)C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 501.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Kanada R, Kagoshima Y, Suzuki T, Nakamura A, Funami H, Watanabe J, Asano M, Takahashi M, Ubukata O, Suzuki K, Aikawa T, Sato K, Goto M, Setsu G, Ito K, Kihara K, Kuroha M, Kohno T, Ogiwara H, Isoyama T, Tominaga Y, Higuchi S, Naito H. Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor. J Med Chem. 2022 Dec 26. doi: 10.1021/acs.jmedchem.2c01641. Epub ahead of print. PMID: 36572866.