TUL01101 is a Janus kinase 1 (JAK1) inhibitor with IC50=3nM. Whole blood assay also demonstrated the high activity and selectivity (37-fold for JAK2). At the same time, TUL01101 also demonstrated excellent metabolic stability and pharmacokinetics (PK) profiles were assayed in three species (mouse, rat, and dog). Moreover, it has been validated for effective activity in the treatment of RA both in collagen-induced arthritis (CIA) and adjuvant-induced arthritis (AIA) models, with low dose and low toxicity.
MedKoo Cat#: 122425
Name: TUL01101
CAS#: N/A
Chemical Formula: C22H25F2N5O2
Exact Mass: 429.1976
Molecular Weight: 429.47
Elemental Analysis: C, 61.53; H, 5.87; F, 8.85; N, 16.31; O, 7.45
The following data is based on the product molecular weight 429.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
