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MedKoo Cat#: 122405 | Name: LG101506
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LG 101506 is a selective RXR modulator (Ki values are 3, 9 and 11 nM for RXRα, RXRβ and RXRγ respectively).

Chemical Structure

LG101506
LG101506
CAS#331248-11-4

Theoretical Analysis

MedKoo Cat#: 122405

Name: LG101506

CAS#: 331248-11-4

Chemical Formula: C25H34F2O3

Exact Mass: 420.2476

Molecular Weight: 420.54

Elemental Analysis: C, 71.40; H, 8.15; F, 9.04; O, 11.41

Price and Availability

Size Price Availability Quantity
10mg USD 525.00 2 Weeks
50mg USD 1,550.00 2 Weeks
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Related CAS #
No Data
Synonym
LG 101506; LG-101506; LG101506
IUPAC/Chemical Name
(2E,4E,6Z)-7-(3,5-di-tert-butyl-2-(2,2-difluoroethoxy)phenyl)-3-methylocta-2,4,6-trienoic acid
InChi Key
BHIBZAZKKARFIM-XRYBSMBUSA-N
InChi Code
InChI=1S/C25H34F2O3/c1-16(12-22(28)29)10-9-11-17(2)19-13-18(24(3,4)5)14-20(25(6,7)8)23(19)30-15-21(26)27/h9-14,21H,15H2,1-8H3,(H,28,29)/b10-9+,16-12+,17-11-
SMILES Code
CC(C)(C)C1=CC(C(C)(C)C)=CC(/C(C)=C\C=C\C(C)=C\C(O)=O)=C1OCC(F)F
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
LG 101506 is a selective RXR modulator (Ki values are 3, 9 and 11 nM for RXRα, RXRβ and RXRγ respectively).
In vitro activity:
In Zucker fatty (fa/fa) rats, LG1506 is a potent insulin sensitizer that also enhances the insulin-sensitizing activities of rosiglitazone. Administration of LG1506 reduces both body weight gain and food consumption and blocks the TZD-induced weight gain when coadministered with rosiglitazone. Reference: Endocrinology. 2006 Feb;147(2):1044-53. https://pubmed.ncbi.nlm.nih.gov/16269450/
In vivo activity:
These molecules (including LG 101506) markedly reduced tumor number, tumor size, and total tumor burden, when chronically administered to A/J mice that had been initiated with the mutagenic carcinogen, vinyl carbamate. Both rexinoids diminished the percentage of high-grade, highly malignant adenocarcinomas found at autopsy. Reference: Cancer Prev Res (Phila). 2016 Jan;9(1):105-14. https://pubmed.ncbi.nlm.nih.gov/26554632/
Solvent mg/mL mM comments
Solubility
DMSO 42.1 100.00
Ethanol 21.0 50.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 420.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Leibowitz MD, Ardecky RJ, Boehm MF, Broderick CL, Carfagna MA, Crombie DL, D'Arrigo J, Etgen GJ, Faul MM, Grese TA, Havel H, Hein NI, Heyman RA, Jolley D, Klausing K, Liu S, Mais DE, Mapes CM, Marschke KB, Michellys PY, Montrose-Rafizadeh C, Ogilvie KM, Pascual B, Rungta D, Tyhonas JS, Urcan MS, Wardlow M, Yumibe N, Reifel-Miller A. Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes. Endocrinology. 2006 Feb;147(2):1044-53. doi: 10.1210/en.2005-0690. Epub 2005 Nov 3. PMID: 16269450. 2. Cao M, Royce DB, Risingsong R, Williams CR, Sporn MB, Liby KT. The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice. Cancer Prev Res (Phila). 2016 Jan;9(1):105-14. doi: 10.1158/1940-6207.CAPR-15-0325. Epub 2015 Nov 10. PMID: 26554632.
In vitro protocol:
1. Leibowitz MD, Ardecky RJ, Boehm MF, Broderick CL, Carfagna MA, Crombie DL, D'Arrigo J, Etgen GJ, Faul MM, Grese TA, Havel H, Hein NI, Heyman RA, Jolley D, Klausing K, Liu S, Mais DE, Mapes CM, Marschke KB, Michellys PY, Montrose-Rafizadeh C, Ogilvie KM, Pascual B, Rungta D, Tyhonas JS, Urcan MS, Wardlow M, Yumibe N, Reifel-Miller A. Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes. Endocrinology. 2006 Feb;147(2):1044-53. doi: 10.1210/en.2005-0690. Epub 2005 Nov 3. PMID: 16269450.
In vivo protocol:
1. Cao M, Royce DB, Risingsong R, Williams CR, Sporn MB, Liby KT. The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice. Cancer Prev Res (Phila). 2016 Jan;9(1):105-14. doi: 10.1158/1940-6207.CAPR-15-0325. Epub 2015 Nov 10. PMID: 26554632.