Synonym
K122; K 122; K-122
IUPAC/Chemical Name
(S)-6-amino-N-((S)-6-amino-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-1-oxohexan-2-yl)-2-((2S,5S,8S,14S)-14-amino-8-(4-aminobutyl)-2,5-diisobutyl-16-methyl-4,7,10-trioxo-12-tosyl-3,6,9,12-tetraazaheptadecanamido)hexanamide
InChi Key
ILUMOZYAPGCWPJ-ULCGJULCSA-N
InChi Code
InChI=1S/C57H105N13O10S/c1-35(2)28-41(61)33-70(81(79,80)42-23-21-40(11)22-24-42)34-50(71)63-43(18-12-15-25-58)52(73)67-49(32-39(9)10)57(78)69-47(30-37(5)6)55(76)65-44(19-13-16-26-59)53(74)64-45(20-14-17-27-60)54(75)68-48(31-38(7)8)56(77)66-46(51(62)72)29-36(3)4/h21-24,35-39,41,43-49H,12-20,25-34,58-61H2,1-11H3,(H2,62,72)(H,63,71)(H,64,74)(H,65,76)(H,66,77)(H,67,73)(H,68,75)(H,69,78)/t41-,43-,44-,45-,46-,47-,48-,49-/m0/s1
SMILES Code
CC(C)C[C@@H](CN(S(=O)(C1=CC=C(C)C=C1)=O)CC(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)N
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
1,164.61
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yang G, Yuan Y, Yuan H, Wang J, Yun H, Geng Y, Zhao M, Li L, Weng Y, Liu Z,
Feng J, Bu Y, Liu L, Wang B, Zhang X. Histone acetyltransferase 1 is a
succinyltransferase for histones and non-histones and promotes tumorigenesis.
EMBO Rep. 2021 Feb 3;22(2):e50967. doi: 10.15252/embr.202050967. Epub 2020 Dec
29. PMID: 33372411; PMCID: PMC7857430.
2: Banks CJ, Rodriguez NW, Gashler KR, Pandya RR, Mortenson JB, Whited MD,
Soderblom EJ, Thompson JW, Moseley MA, Reddi AR, Tessem JS, Torres MP, Bikman
BT, Andersen JL. Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs
SOD1-Mediated Inhibition of Mitochondrial Respiration. Mol Cell Biol. 2017 Sep
26;37(20):e00354-17. doi: 10.1128/MCB.00354-17. PMID: 28739857; PMCID:
PMC5615182.
3: Nam MH, Smith AJO, Pantcheva MB, Park KU, Brzezinski JA, Galligan JJ, Fritz
K, Wormstone IM, Nagaraj RH. Aspirin inhibits TGFβ2-induced epithelial to
mesenchymal transition of lens epithelial cells: selective acetylation of K56
and K122 in histone H3. Biochem J. 2020 Jan 17;477(1):75-97. doi:
10.1042/BCJ20190540. PMID: 31815277; PMCID: PMC8259308.