MedKoo Cat#: 122391 | Name: K122

Description:

WARNING: This product is for research use only, not for human or veterinary use.

K122 is an antibacterial agent and is an AMP Feleucin-K3 analogue modified with unnatural peptidomimetic sulfono-γ-AA building block. K122 exhibited potent and broadspectrum antimicrobial activity and high selectivity. K122 had a rapid bactericidal effect and a low tendency to induce resistance. Surprisingly, K122 showed excellent effectiveness against bacterial pneumonia. For biofilm and local skin infections, K122 significantly decreased the bacterial load and improved tissue injury at a dose of only 0.25 mg/kg, which was 160 times lower than the concentration deemed to be safe for local dermal applications.

Chemical Structure

K122
K122
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 122391

Name: K122

CAS#: N/A

Chemical Formula: C57H105N13O10S

Exact Mass: 1163.7828

Molecular Weight: 1164.61

Elemental Analysis: C, 58.79; H, 9.09; N, 15.64; O, 13.74; S, 2.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
K122; K 122; K-122
IUPAC/Chemical Name
(S)-6-amino-N-((S)-6-amino-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-1-oxohexan-2-yl)-2-((2S,5S,8S,14S)-14-amino-8-(4-aminobutyl)-2,5-diisobutyl-16-methyl-4,7,10-trioxo-12-tosyl-3,6,9,12-tetraazaheptadecanamido)hexanamide
InChi Key
ILUMOZYAPGCWPJ-ULCGJULCSA-N
InChi Code
InChI=1S/C57H105N13O10S/c1-35(2)28-41(61)33-70(81(79,80)42-23-21-40(11)22-24-42)34-50(71)63-43(18-12-15-25-58)52(73)67-49(32-39(9)10)57(78)69-47(30-37(5)6)55(76)65-44(19-13-16-26-59)53(74)64-45(20-14-17-27-60)54(75)68-48(31-38(7)8)56(77)66-46(51(62)72)29-36(3)4/h21-24,35-39,41,43-49H,12-20,25-34,58-61H2,1-11H3,(H2,62,72)(H,63,71)(H,64,74)(H,65,76)(H,66,77)(H,67,73)(H,68,75)(H,69,78)/t41-,43-,44-,45-,46-,47-,48-,49-/m0/s1
SMILES Code
CC(C)C[C@@H](CN(S(=O)(C1=CC=C(C)C=C1)=O)CC(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)N
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,164.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yang G, Yuan Y, Yuan H, Wang J, Yun H, Geng Y, Zhao M, Li L, Weng Y, Liu Z, Feng J, Bu Y, Liu L, Wang B, Zhang X. Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis. EMBO Rep. 2021 Feb 3;22(2):e50967. doi: 10.15252/embr.202050967. Epub 2020 Dec 29. PMID: 33372411; PMCID: PMC7857430. 2: Banks CJ, Rodriguez NW, Gashler KR, Pandya RR, Mortenson JB, Whited MD, Soderblom EJ, Thompson JW, Moseley MA, Reddi AR, Tessem JS, Torres MP, Bikman BT, Andersen JL. Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration. Mol Cell Biol. 2017 Sep 26;37(20):e00354-17. doi: 10.1128/MCB.00354-17. PMID: 28739857; PMCID: PMC5615182. 3: Nam MH, Smith AJO, Pantcheva MB, Park KU, Brzezinski JA, Galligan JJ, Fritz K, Wormstone IM, Nagaraj RH. Aspirin inhibits TGFβ2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3. Biochem J. 2020 Jan 17;477(1):75-97. doi: 10.1042/BCJ20190540. PMID: 31815277; PMCID: PMC8259308.