MedKoo Cat#: 122159 | Name: VHL Ligand 1 HCl salt
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VHL Ligand 1 HCl salt is a synthetic E3 ligase ligand that is useful for PROTAC drug research & discovery. VHL Ligand 1 works by binding the Hippel-Lindau (VHL) E3 ligase portion of VHL-based PROTACs.

Chemical Structure

VHL Ligand 1 HCl salt
VHL Ligand 1 HCl salt
CAS#1448189-80-7

Theoretical Analysis

MedKoo Cat#: 122159

Name: VHL Ligand 1 HCl salt

CAS#: 1448189-80-7

Chemical Formula: C22H30N4O3S

Exact Mass: 430.2039

Molecular Weight: 430.60

Elemental Analysis: C, 61.37; H, 7.02; N, 13.01; O, 11.15; S, 7.45

Price and Availability

Size Price Availability Quantity
250mg USD 450.00 2 Weeks
500mg USD 750.00 2 Weeks
1g USD 1,050.00 2 Weeks
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Related CAS #
No Data
Synonym
VHL Ligand 1 HCl salt
IUPAC/Chemical Name
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChi Key
ZLOXMSNKPDWMEF-ZIFCJYIRSA-N
InChi Code
InChI=1S/C22H30N4O3S/c1-13-18(30-12-25-13)15-7-5-14(6-8-15)10-24-20(28)17-9-16(27)11-26(17)21(29)19(23)22(2,3)4/h5-8,12,16-17,19,27H,9-11,23H2,1-4H3,(H,24,28)/t16-,17+,19-/m1/s1
SMILES Code
N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 430.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL